H1664

Hemokinin 1 human

≥98% (HPLC), solid

• Synonym(s): hHK-1
• Empirical Formula (Hill Notation): C₅₄H₈₂N₁₄O₁₄S
• CAS Number: 491851-53-7
• Molecular Weight: 1183.38
• MDL number: MFCD06656083
• UNSPSC Code: 12352202
• PubChem Substance ID: 329815175
• NACRES: NA.32

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: solid
• color: white
• UniProt accession no.: Q86UU9
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@@H](N)[C@@H](C)O)C(N)=O
• InChI: 1S/C54H84N14O14S/c1-30(2)24-38(51(79)64-35(46(58)74)21-23-83-5)63-44(73)27-59-48(76)39(25-33-14-8-6-9-15-33)66-52(80)40(26-34-16-10-7-11-17-34)67-50(78)37(19-20-42(56)71)65-53(81)41(29-69)68-47(75)31(3)61-49(77)36(18-12-13-22-55)62-43(72)28-60-54(82)45(57)32(4)70/h6-11,14-17,30-32,35-41,45,69-70H,12-13,18-29,55,57H2,1-5H3,(H2,56,71)(H2,58,74)(H,59,76)(H,60,82)(H,61,77)(H,62,72)(H,63,73)(H,64,79)(H,65,81)(H,66,80)(H,67,78)(H,68,75)/t31-,32+,35-,36-,37-,38-,39-,40-,41-,45-/m0/s1
• InChI key: NYBLUYYRUFKGTB-XJCFQSCISA-N

Description

Amino Acid Sequence

Thr-Gly-Lys-Ala-Ser-Gln-Phe-Phe-Gly-Leu-Met-NH2

General description

Hemokinin 1 (HK1) is a a member of the tachykinin peptide family with broad expression, particularly in brain areas.[1]

Biochem/physiol Actions

Hemokinin 1 (HK1) is an endogenous agonist for all tachykinin receptors. However, it is highly selective for the NK1 (neurokinin 1) receptor. HK1 and substance-P compete with each other for binding to NK1.[2] HK1 is involved in the B-cell as well as T-cell development.[1]

NK₁ tachykinin receptor agonist.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves