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Key Documents

L1294

Sigma-Aldrich

Lactoferrin human

recombinant, expressed in rice, Iron saturated, ≥90% (SDS-PAGE)

Synonym(s):

Holo Transferrin

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About This Item

MDL number:
UNSPSC Code:
12352202
NACRES:
NA.25

biological source

human

Quality Level

recombinant

expressed in rice

type

for cell culture

Assay

≥90% (SDS-PAGE)
≥90% (biuret)

form

powder

technique(s)

microbiological culture: suitable

impurities

≤10 EU/mg endotoxin

UniProt accession no.

storage temp.

2-8°C

Gene Information

human ... LTF(4057)

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Application

Lactoferrin was used to grow Streptococcus mutans in an iron-limiting medium. It was used to test if lactoferrin impedes epithelial cell adhesion in vitro.

Biochem/physiol Actions

Lactoferrin is an iron binding protein. It is structurally similar to transferrin, the plasma iron transport protein; but lactoferrin has a much higher affinity for iron (250 fold). It is very abundant in colostrum and small amounts can also be found in tears, saliva, mucous secretions and in the secondary granules of neutrophils. It is made by mucosal epithelium and neutrophils and is released by these cells in response to inflammatory stimuli. Bacterial growth is inhibited by its ability to sequester iron and also permeabilize bacterial cell walls by binding to lipopolysaccharides through its N-terminus. Lactoferrin can inhibit viral infection by binding tightly to the viral envelope protein. This prevents cell-virus fusion by blocking the binding domain. Lactoferrin appears to activate host defense systems in part by stimulating the release of interleukin-8, a neutrophil activator. It may also be involved in antibody and interleukin synthesis, lymphocyte proliferation and complement activation.

Other Notes

rhLactoferrin manufactured in the USA by InVitria.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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