L1294
Lactoferrin human
recombinant, expressed in rice, Iron saturated, ≥90% (SDS-PAGE)
Synonym(s):
Holo Transferrin
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About This Item
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biological source
human
Quality Level
recombinant
expressed in rice
type
for cell culture
Assay
≥90% (SDS-PAGE)
≥90% (biuret)
form
powder
technique(s)
microbiological culture: suitable
impurities
≤10 EU/mg endotoxin
UniProt accession no.
storage temp.
2-8°C
Gene Information
human ... LTF(4057)
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Application
Lactoferrin was used to grow Streptococcus mutans in an iron-limiting medium. It was used to test if lactoferrin impedes epithelial cell adhesion in vitro.
Biochem/physiol Actions
Lactoferrin is an iron binding protein. It is structurally similar to transferrin, the plasma iron transport protein; but lactoferrin has a much higher affinity for iron (250 fold). It is very abundant in colostrum and small amounts can also be found in tears, saliva, mucous secretions and in the secondary granules of neutrophils. It is made by mucosal epithelium and neutrophils and is released by these cells in response to inflammatory stimuli. Bacterial growth is inhibited by its ability to sequester iron and also permeabilize bacterial cell walls by binding to lipopolysaccharides through its N-terminus. Lactoferrin can inhibit viral infection by binding tightly to the viral envelope protein. This prevents cell-virus fusion by blocking the binding domain. Lactoferrin appears to activate host defense systems in part by stimulating the release of interleukin-8, a neutrophil activator. It may also be involved in antibody and interleukin synthesis, lymphocyte proliferation and complement activation.
Other Notes
rhLactoferrin manufactured in the USA by InVitria.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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