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About This Item
Empirical Formula (Hill Notation):
C29H31N3O3 · 2 HCl · xH2O
CAS Number:
Molecular Weight:
542.50 (anhydrous basis)
MDL number:
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
Product Name
MPP dihydrochloride hydrate, ≥97% (HPLC), white, powder
Quality Level
Assay
≥97% (HPLC)
form
powder
storage condition
desiccated
color
white
solubility
DMSO: soluble ≥20 mg/mL
SMILES string
Cl.Cl.Cc1c(nn(-c2ccc(O)cc2)c1-c3ccc(OCCN4CCCCC4)cc3)-c5ccc(O)cc5
InChI
1S/C29H31N3O3.2ClH/c1-21-28(22-5-11-25(33)12-6-22)30-32(24-9-13-26(34)14-10-24)29(21)23-7-15-27(16-8-23)35-20-19-31-17-3-2-4-18-31;;/h5-16,33-34H,2-4,17-20H2,1H3;2*1H
InChI key
FWDNPWVVRVSJQH-UHFFFAOYSA-N
General description
Methyl-piperidino-pyrazole hydrate (MPP) is prepared from a methyl-pyrazole-triol (MPT), a pyrazole triol.
Application
MPP dihydrochloride hydrate has been used as an estrogen receptor α antagonist:
- in human breast cancer MCF-7 cells
- to pre-treat endometrial ex vivo organ cultures (EVOCs)
- to treat pituitary glands to monitor luteinizing hormone secretion
Biochem/physiol Actions
MPP dihydrochloride is a specific estrogen receptor α antagonist.
Methyl-piperidino-pyrazole hydrate (MPP) is an agonist for estrogen receptor α and lacks any ligand functionality with estrogen receptor (ER)β. It promotes silibinin induced apoptosis in human breast cancer MCF-7 cells.
Specific estrogen receptor α antagonist.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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