M7441

Monoamine Oxidase B human

recombinant, expressed in baculovirus infected BTI insect cells

• Synonym(s): MAO-B
• EC Number: 1.4.3.4 (BRENDA, IUBMB)
• MDL number: MFCD04040933
• UNSPSC Code: 12352204
• NACRES: NA.54

Properties

• recombinant: expressed in baculovirus infected BTI insect cells
• Quality Level: 100
• form: liquid
• enzyme activity: ≥1 U/mg
• packaging: vial of ~2.5 mg
• UniProt accession no.: P27338
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... MAOB(4129)

Description

General description

Monoamine Oxidase B is a mitochondrial outermembrane flavoenzyme that is a target for antidepressant and neuroprotective drugs.

Application

Drugs that inhibit monoamine oxidase B activity are used for the treatment of various neurological disorders including depression.

Monoamine Oxidase B has been used in a study to assess the effect of age in 23 different regions of the human brain. It has also been used in a study to determine the specific locations of monoamine oxidase in the human brain.

Biochem/physiol Actions

MAO′s are proteins of the mitochondrial membrane. These enzymes are responsible for catalyzing oxidative deamination of endo- and xenobiotic amines. Substrate specificity differs for each isozyme.

Unit Definition

kynuramine deamination activity: One unit will deaminate 1 nanomole of kynuramine per minute at pH 7.4 at 37 deg C.

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves