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P7265

Sigma-Aldrich

Prostaglandin A1

≥98% (HPLC), powder, NF-κB inhibitor

Synonym(s):

(13E,15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid, PGA1

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About This Item

Empirical Formula (Hill Notation):
C20H32O4
CAS Number:
14152-28-4
Molecular Weight:
336.47
Beilstein:
2003401
MDL number:
MFCD00077858
UNSPSC Code:
12352211
PubChem Substance ID:
24898834
NACRES:
NA.77
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Product Name

Prostaglandin A1, synthetic

biological source

synthetic

Quality Level

200

Assay

≥98%

form

powder

storage temp.

−20°C

SMILES string

O=C1[C@H](CCCCCCC(O)=O)[C@@H](/C=C/[C@H](CCCCC)O)C=C1

InChI

1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/b14-12+/t16-,17-,18+/m0/s1

InChI key

BGKHCLZFGPIKKU-LDDQNKHRSA-N

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Show Differences

1 of 4

This Item
602175602159602205
Xenon-131Xe 60 atom %

602167

Xenon-131Xe

Xenon-131Xe 80 atom %

602175

Xenon-131Xe

Xenon-131Xe 99 atom %

602159

Xenon-131Xe

Xenon-134Xe 60 atom %

602205

Xenon-134Xe

assay

≥99.5% (Total Xenon)

assay

≥99.5% (Total Xenon)

assay

≥99.5% (Total Xenon)

assay

≥99.5% (Total Xenon)

mass shift

M-1

mass shift

M-1

mass shift

M-1

mass shift

M+2

isotopic purity

60 atom %

isotopic purity

80 atom %

isotopic purity

99 atom %

isotopic purity

60 atom %

form

gas

form

gas

form

gas

form

gas

impurities

<0.5% Total others

impurities

<0.5% Total others

impurities

<0.5% Total others

impurities

<0.5% Total others

Biochem/physiol Actions

Prostaglandin A1 (PGA1) is a cyclopentenone prostaglandin containing chemically reactive α,β-unsaturated carbonyl. This cyclooxygenase 2 (COX-2) metabolic product aids in regulating the development and progression of Alzheimer′s disease (AD). In addition, PGA1 also regulates various biological processes via Michael addition. It exhibits antiviral activity against avian influenza A viruses (IAV) by inducing cytoprotective heat shock response in infected cells and by inhibiting nuclear factor-κB (NF-κB) activity.

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Danger

Hazard Statements

H302,H360F

Hazard Classifications

Acute Tox. 4 Oral - Repr. 1B

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
SLCH6895
SLCG9282
SLCG0814
SLCF6883
SLCF1385

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