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P7265

Sigma-Aldrich

Prostaglandin A1

≥98% (HPLC), powder, NF-κB inhibitor

Synonym(s):

(13E,15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid, PGA1

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About This Item

Empirical Formula (Hill Notation):
C20H32O4
CAS Number:
Molecular Weight:
336.47
Beilstein:
2003401
MDL number:
UNSPSC Code:
12352211
PubChem Substance ID:
NACRES:
NA.77
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Product Name

Prostaglandin A1, synthetic

biological source

synthetic

Quality Level

Assay

≥98%

form

powder

storage temp.

−20°C

SMILES string

O=C1[C@H](CCCCCCC(O)=O)[C@@H](/C=C/[C@H](CCCCC)O)C=C1

InChI

1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/b14-12+/t16-,17-,18+/m0/s1

InChI key

BGKHCLZFGPIKKU-LDDQNKHRSA-N

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1 of 4

This Item
602175602159602205
assay

≥99.5% (Total Xenon)

assay

≥99.5% (Total Xenon)

assay

≥99.5% (Total Xenon)

assay

≥99.5% (Total Xenon)

mass shift

M-1

mass shift

M-1

mass shift

M-1

mass shift

M+2

isotopic purity

60 atom %

isotopic purity

80 atom %

isotopic purity

99 atom %

isotopic purity

60 atom %

form

gas

form

gas

form

gas

form

gas

impurities

<0.5% Total others

impurities

<0.5% Total others

impurities

<0.5% Total others

impurities

<0.5% Total others

Biochem/physiol Actions

Prostaglandin A1 (PGA1) is a cyclopentenone prostaglandin containing chemically reactive α,β-unsaturated carbonyl. This cyclooxygenase 2 (COX-2) metabolic product aids in regulating the development and progression of Alzheimer′s disease (AD). In addition, PGA1 also regulates various biological processes via Michael addition. It exhibits antiviral activity against avian influenza A viruses (IAV) by inducing cytoprotective heat shock response in infected cells and by inhibiting nuclear factor-κB (NF-κB) activity.

Pictograms

Health hazardExclamation mark

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Repr. 1B

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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