biological source
goat
Quality Level
antibody form
affinity purified immunoglobulin
antibody product type
primary antibodies
species reactivity
human
technique(s)
immunoprecipitation (IP): 2-5 μg/mg
western blot: 1:2,000-1:10,000
accession no.
NP_000042.2
UniProt accession no.
shipped in
wet ice
storage temp.
2-8°C
Gene Information
goat ... ATM(472)
Immunogen
The epitope recognized by PLA0045 maps to a region between residues 2550 and 2600 of human Ataxia Telangiectasia Mutated using the numbering given in entry NP_000042.2 (GeneID 472).
Physical form
Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% sodium azide
Other Notes
Ataxia telangiectasia, mutated (ATM) is the gene responsible for the neurodegenerative disease ataxia telangiectasia (AT). AT is characterized by neurodegeneration, immune dysfunction, sensitivity to DNA damage, and cancer predisposition. ATM is a protein kinase central to the DNA damage response. In response to DNA double-strand breaks (DSBs), ATM initiates a signaling cascade that involves the phosphorylation of a multitude of substrates which include p53, BRCA1, p53 binding protein, CHK2, RAD9, RAD17, and MDM4.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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