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SAB1404243

Sigma-Aldrich

Monoclonal Anti-PRKCI, (N-terminal) antibody produced in mouse

clone 3A7, purified immunoglobulin, buffered aqueous solution

Synonym(s):

DXS1179E, MGC26534, PKCI, nPKC-iota

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
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biological source

mouse

Quality Level

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

3A7, monoclonal

form

buffered aqueous solution

mol wt

antigen ~37.11 kDa

species reactivity

human

technique(s)

capture ELISA: suitable
indirect ELISA: suitable
western blot: 1-5 μg/mL

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This Item
GF23463165GF45219922GF23312225
manufacturer/tradename

Goodfellow 852-395-02

manufacturer/tradename

Goodfellow 234-631-65

manufacturer/tradename

Goodfellow 452-199-22

manufacturer/tradename

Goodfellow 233-122-25

assay

≥99%

assay

≥99%

assay

≥99%

assay

≥99%

form

wire

form

wire

form

wire

form

wire

L

1 m

L

1 m

L

0.2 m

L

2 m

diameter

0.5 mm

diameter

0.38 mm

diameter

1 mm

diameter

0.5 mm

General description

This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. (provided by RefSeq)

Immunogen

PRKCI (AAH22016, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
MSHTVAGGGSGDHSHQVRVKAYYRGDIMITHFEPSISFEGLCNEVRDMCSFDNEQLFTMKWIDEEGDPCTVSSQLELEEAFRLYELNKDSELLIHVFPCV

Physical form

Solution in phosphate buffered saline, pH 7.4

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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