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SAB4300458

Sigma-Aldrich

Anti-RPS6KA5 (Ab-376) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-MGC1911 antibody produced in rabbit, Anti-MSK1 antibody produced in rabbit, Anti-MSPK1 antibody produced in rabbit, Anti-RLPK antibody produced in rabbit, Anti-ribosomal protein S6 kinase, 90kDa, polypeptide 5 antibody produced in rabbit

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About This Item

MDL number:
MFCD02686432
UNSPSC Code:
12352203
NACRES:
NA.41
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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~90 kDa

species reactivity

human

concentration

1 mg/mL

Related Categories

General description

RPS6KA5 (ribosomal protein S6 kinase A5)/mitogen- and stress-activated kinase 1 (MSK1) is a nuclear serine/threonine protein kinase , that is located on human chromosome 14q32. It is a dual kinase domain protein.

Immunogen

Peptide sequence around aa. 374-378 (G-Y-S-F-V), according to the protein RPS6KA5.

Biochem/physiol Actions

RPS6KA5 (ribosomal protein S6 kinase A5)/mitogen- and stress-activated kinase 1 (MSK1) acts as a connector between extracellular signals and gene expression. It helps in the phosphorylation of chromatin protein histone H3 and high mobility group 14 (HMG14) . MSK1 plays a key role in the development of hormone-dependent breast cancer.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Target description

Serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). Essential role in the control of RELA transcriptional activity in response to TNF. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14).

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
871521198

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