SML1362

L755507

≥98% (HPLC)

• Synonym(s): 4-[[(Hexylamino)carbonyl]amino]-N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]-benzenesulfonamide, L-755,507
• Empirical Formula (Hill Notation): C₃₀H₄₀N₄O₆S
• CAS Number: 159182-43-1
• Molecular Weight: 584.73
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825817
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: OC1=CC=C(OC[C@@H](O)CNCCC2=CC=C(NS(C3=CC=C(NC(NCCCCCC)=O)C=C3)(=O)=O)C=C2)C=C1
• InChI: 1S/C30H40N4O6S/c1-2-3-4-5-19-32-30(37)33-24-10-16-29(17-11-24)41(38,39)34-25-8-6-23(7-9-25)18-20-31-21-27(36)22-40-28-14-12-26(35)13-15-28/h6-17,27,31,34-36H,2-5,18-22H2,1H3,(H2,32,33,37)/t27-/m0/s1
• InChI key: NYYJKMXNVNFOFQ-MHZLTWQESA-N

Description

General description

L755507 is a derivative of 4-acylaminobenzenesulfonamide.

Application

L755507 has been shown to enhance CRISPR genome editing efficiency. To see other small molecule CRISPR enhancers, visit sigma.com/CRISPR-enhancers.

Biochem/physiol Actions

L755507 is a potent β3-adrenergic receptor partial agonist with an EC₅₀ value of 0.43 nM for β3 receptors with over 440-fold selectivity for β3 compared to β1 and β2-adrenergic receptor binding. L755507 has been shown to enhance CRISPR-mediated homology-directed repair (HDR) efficiency in human induced pluripotent stem cells (iPSCs), increasing the efficiency of GFP insertion by 3-fold compared to control cells.

L755507 is a potent β3-adrenergic receptor partial agonist.

L755507 is found to stimulate the breakdown of lipids in human adipose tissues. L755507 also promotes urinary bladder relaxation.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable