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SML1770

Sigma-Aldrich

PhiKan083 hydrochloride

≥98% (HPLC)

Synonym(s):

9-Ethyl-N-methyl-9H-Carbazole-3-methanamine hydrochloride, PK-083 hydrochloride, PK083 hydrochloride, PhiKan-083 hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C16H18N2 · HCl
CAS Number:
1050480-30-2
Molecular Weight:
274.79
MDL number:
MFCD07168924
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

CNCC1=CC2=C(C=C1)N(CC)C3=C2C=CC=C3.[H]Cl

InChI key

IXWVUPURFWFRNE-UHFFFAOYSA-N

Biochem/physiol Actions

Mutant p53 stabilizer
PhiKan083 is a small molecule that binds within a cavity on the surface of Y220C-mutated p53. This mutation, which is not involved in DNA interaction, causes a destabilization of the protein. PhiKan083 binding acts to stabilize the mutant p53 and slow the rate of denaturation.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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