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SML2524

Sigma-Aldrich

Fexinidazole

≥98% (HPLC)

Synonym(s):

1-methyl-2-[[4-(methylthio)phenoxy]methyl]-5-nitro-1H-imidazole, HOE 239

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100 μG
RM 1,723.00

About This Item

Empirical Formula (Hill Notation):
C12H13N3O3S
CAS Number:
59729-37-2
Molecular Weight:
279.31
MDL number:
MFCD00866607
UNSPSC Code:
12352200
NACRES:
NA.77

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Assay

≥98% (HPLC)

form

powder

color

light yellow to dark brown

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

CN1C(COC2=CC=C(SC)C=C2)=NC=C1[N+]([O-])=O

InChI

1S/C12H13N3O3S/c1-14-11(13-7-12(14)15(16)17)8-18-9-3-5-10(19-2)6-4-9/h3-7H,8H2,1-2H3

InChI key

MIWWSGDADVMLTG-UHFFFAOYSA-N

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Fexinidazole ≥98% (HPLC)

SML2524

Fexinidazole

Secnidazole ≥98% (HPLC)

SML2613

Secnidazole

BAZ2-ICR ≥98% (HPLC)

SML1276

BAZ2-ICR

ZCZ011 ≥98% (HPLC)

SML2710

ZCZ011

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear

solubility

H2O: 2 mg/mL, clear (warmed)

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

color

light yellow to dark brown

color

white to beige

color

white to beige

color

white to beige

Biochem/physiol Actions

Anti Trypanosoma, Leishmania agent.
Fexinidazole is a potent anti-Trypanosoma agent. Trypanosoma species human protozoan pathogens are responsible for sleeping sickness and Chagas disease. In vivo, fexinidazole is oxidized to sulfoxide and sulfone metabolites that are effective in blocking the progression of the parasitic disease visceral leishmaniasis. The mechanism of action appears to be by reductive activation via an NADH-dependent nitroreductase expressed by the parasites.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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