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SRP2097

Sigma-Aldrich

HIF-1 α, C-terminal activation domain (776-826 human

recombinant, expressed in E. coli, ≥85% (SDS-PAGE)

Synonym(s):

HIF-1alpha, HIF1, HIF1-alpha, MOP1, PASD8, bHLHe78

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10 MG
294 756 KRW
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984 550 KRW

294 756 KRW


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10 MG
294 756 KRW
50 MG
984 550 KRW

About This Item

UNSPSC Code:
12352200
NACRES:
NA.26

294 756 KRW


Please contact Customer Service for Availability

Request a Bulk Order
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biological source

human

recombinant

expressed in E. coli

Assay

≥85% (SDS-PAGE)

form

frozen liquid

mol wt

~6.7 kDa

packaging

pkg of 10 μg

storage condition

avoid repeated freeze/thaw cycles

concentration

700 μg/mL

color

colorless to clear

NCBI accession no.

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This Item
G1421SML0686UC175
Tofisopam ≥98% (HPLC), solid

T8200

Tofisopam

form

solid

form

solid

form

powder

form

solid

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥97% (HPLC)

assay

≥98% (HPLC)

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

drug control

-

drug control

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

200

solubility

DMSO: ~14 mg/mL, H2O: insoluble

solubility

DMSO: soluble >10 mg/mL, H2O: insoluble <2 mg/mL

solubility

DMSO: 15 mg/mL, clear

solubility

DMSO: soluble

color

white

color

white to pink

color

white to beige

color

off-white

General description

The gene encoding it is localized on human chromosome 14q23.2.[1]

Biochem/physiol Actions

During hypoxia, the two subunits of this factor undergo post-translational modifications which in turn promote transactivation.[2]
Hypoxia-inducible factor-1 (HIF1) is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia.
Hypoxia-inducible factor-1 (HIF1) is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has been identified as the aryl hydrocarbon receptor nuclear translocator (ARNT). This gene encodes the alpha subunit of HIF-1. HIF-1α contains two transactivation domains located between amino acids 531 and 826. Overexpression of a natural antisense transcript (aHIF) of this gene has been shown to be associated with nonpapillary renal carcinomas. Two alternative transcripts encoding different isoforms have been identified. Specific disruption of the HIF-1 pathway is important for exploring its role in tumor biology and developing more efficient weapons to treat cancer. HIF-1alpha is a master regulator of the hypoxic response, and its proangiogenic activities include, but are not limited to, regulation of vascular endothelial growth factor (VEGF). HIF-1alpha protein expression often seen in invasive breast cancer. Recent data demonstrates that HIF-1alpha knockdown reduces tumorigenicity of MCF-7 cells and suggest a promising combination of both anti-HIF-1 strategy and traditional chemotherapy to improve cancer treatment.

Physical form

Clear and colorless frozen liquid solution

Preparation Note

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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    Maria Tóth et al.
    Journal of pharmaceutical and biomedical analysis, 41(4), 1354-1359 (2006-05-10)
    Tofisopam (1-(3,4-dimethoxyphenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5H-2,3-benzodiazepine) has been shown to be an effective anxiolytic agent in the wide-ranging clinical practice. A high sensitive gas chromatography nitrogen phosphorous detection (GC-NPD) bioanalytical method was developed and validated for the purpose of pharmacokinetic study of tofisopam. A
    N P Vanchakova et al.
    Bulletin of experimental biology and medicine, 148(2), 343-345 (2009-12-23)
    The study demonstrated high anxiolytic activity of tenoten, which was not inferior to the anxiolytic effect of grandaxin. The positive changes persisted after termination of treatment in the tenoten group (but not in grandaxin group). Tenoten can be recommended for
    Drug repositioning: identifying and developing new uses for existing drugs.
    Ted T Ashburn et al.
    Nature reviews. Drug discovery, 3(8), 673-683 (2004-08-03)
    Michael D Cameron et al.
    Drug metabolism and disposition: the biological fate of chemicals, 35(10), 1894-1902 (2007-07-25)
    In vitro studies were conducted to elucidate the metabolic profiles of and the enzymes responsible for the metabolism of (R)- and (S)-tofisopam (1-(3,4-dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl-5H-2,3-benzodiazepine). Large differences were observed between the two enantiomers. The major metabolite in incubations of 500 ng/ml (approximately
    N Bonnet et al.
    Toxicology and applied pharmacology, 221(1), 111-118 (2007-03-27)
    The aim of this study was to evaluate the effects of various drugs which present antidepressant properties: selective serotonin-reuptake inhibitors (SSRIs, fluoxetine), serotonin and noradrenaline-reuptake inhibitors (Desipramine) and phosphodiesterase inhibitors (PDE, rolipram and tofisopam) on bone microarchitecture and biomechanical properties.

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