T0577

D-δ-Tocotrienol

from rice, ≥65% (GC)

• Synonym(s): (R-(E,E))-3,4-Dihydro-2,8-dimethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-2H-1-benzopyran-6-ol
• Empirical Formula (Hill Notation): C₂₇H₄₀O₂
• CAS Number: 25612-59-3
• Molecular Weight: 396.61
• UNSPSC Code: 12352205
• NACRES: NA.79

Properties

• biological source: rice
• Quality Level: 100
• form: liquid
• concentration: ≥65% (GC)
• color: yellow to orange
• storage temp.: −20°C
• SMILES string: O1[C@@](CCc2c1c(cc(c2)O)C)(CC\C=C(\CC\C=C(\CCC=C(C)C)/C)/C)C
• InChI: 1S/C27H40O2/c1-20(2)10-7-11-21(3)12-8-13-22(4)14-9-16-27(6)17-15-24-19-25(28)18-23(5)26(24)29-27/h10,12,14,18-19,28H,7-9,11,13,15-17H2,1-6H3/b21-12+,22-14+/t27-/m1/s1
• InChI key: ODADKLYLWWCHNB-LDYBVBFYSA-N

Description

General description

D-δ-Tocotrienol is a bioavailable isomer of vitamin E and has farnesyl side chain.[1] Palm oil is rich in δ-Tocotrienol.[2][3]

Biochem/physiol Actions

D-δ-Tocotrienol suppresses ras sarcoma (Ras) protein levels.[1] It elicits anti-proliferative functionality in melanoma cells by halting cell cycle and favoring apoptosis.[4] δ-Tocotrienol is cytotoxic to human lung adenocarcinoma and glioblastoma cancer cells.[3] δ-Tocotrienol possesses anti-inflammatory, antidiabetic and neuroprotective functionality. It is an effective hypocholesterolemic agent and an inhibitor of lipid peroxidation.[5]

Tocotrienols are widely utilized for their strong antioxidant properties. The various isoforms of tocotrienols differ in their methyl substitution in the chromanol head. δ-tocotrienol, effectively blocks cleavage of SREBPs, ultimately decreasing the amount of cholesterol synthesized in the liver.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves