T1126

Thyroglobulin from porcine thyroid gland

powder

• Synonym(s): TG human
• CAS Number: 9010-34-8
• EC Number: 232-721-3
• MDL number: MFCD00132429
• UNSPSC Code: 12352202
• NACRES: NA.61

Properties

• biological source: Porcine thyroid
• form: powder
• mol wt: ~670 kDa
• composition: Iodine, ≥0.3%
• nitrogen analysis: 14.0-17.5% total
• technique(s): protein purification: suitable
• ash: ≤4%
• pI: 4.58
• UniProt accession no.: F1RRV3
• storage temp.: −20°C
• Gene Information: pig ... TG(100156471)

Description

Biochem/physiol Actions

Thyroglobulin has been shown to regulate the transcription of iodide porters including sodium iodide symporter and pendrin.

Thyroglobulin is a major protein involved with iodine metabolism. It consists of an iodine-containing protein that is stored in the thyroid gland and is converted into circulating thyroxines when the thyroid is stimulated by TSH (Thyroid Stimulating Hormone) from the pituitary. Thyroglobulin is often used as a carrier protein for the production of antibodies. Its advantage as a carrier protein comes from its large number of tyrosine residues that can be used for conjugation using the diazo reaction.

Other Notes

Electrophoretically heterogeneous.

Preparation Note

When reconstituted in water (20 mg/ml), a turbid solution with some insolubles is observed.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves