V9879

[Arg⁸]-Vasopressin acetate salt

≥95% (HPLC)

• Synonym(s): β-Hypophamine, AVP, Antidiuretic hormone, Arginine vasopressin
• Empirical Formula (Hill Notation): C₄₆H₆₅N₁₅O₁₂S₂ · xC₂H₄O₂
• CAS Number: 113-79-1
• Molecular Weight: 1084.23 (free base basis)
• EC Number: 204-035-4
• MDL number: MFCD00133939
• UNSPSC Code: 51111800
• PubChem Substance ID: 24900773
• NACRES: NA.32
• Biological source: synthetic (organic)
• Form: powder

Properties

• biological source: synthetic (organic)
• Quality Level: 200
• sterility: non-sterile
• Assay: ≥95% (HPLC)
• form: powder
• solubility: water: 20.0-20.8 mg/mL, clear, colorless to faintly yellow
• UniProt accession no.: P01185; P30518; P37288; P47901
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: CC(O)=O.N[C@H]1CSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc3ccc(O)cc3)NC1=O)C(=O)N4CCC[C@H]4C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O

Description

Amino Acid Sequence

Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2 [Disulfide Bridge: 1-6]

General description

Arginine vasopressin is a nonapeptide. It is produced by anterior hypothalamus nerve cells.

Application

[Arg8]-Vasopressin acetate salt has been:

• used as a vasopressin receptor agonist to test vasopressin receptors
• used to evoke peripheral V1a receptor-mediated vasoconstriction
• as a supplement in Ham′s F12/Dulbecco′s modified Eagle′s medium for proximal tubule and glomerular explant cell culture

Biochem/physiol Actions

Endogenous antidiuretic hormone in most mammalian species. It is released into the blood from nerve terminals in the posterior pituitary and median eminence. Arg⁸-vasopressin is also a neurotransmitter in the central nervous system. It is implicated in a variety of physiological processes including diuresis, vasoregulation, and memory. Regulates water balance by antidiuretic action; contracts arterioles (vasopressor action).

Endogenous antidiuretic hormone in most mammalian species; neurotransmitter in the central nervous system implicated in a variety of physiological processes including diuresis, vasoregulation, and memory.

Preparation Note

[Arg8]-Vasopressin acetate salt dissolves water at 20 mg/ml to yield a clear colorless to faint yellow solution.

Other Notes

Lyophilized from 0.5% acetic acid

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves