1286413

Frovatriptan succinate

United States Pharmacopeia (USP) Reference Standard

• Synonym(s): Frovatriptan succinate monohydrate, Frovatriptan succinate, R-(+) 3-Methylamino-6-carboxamido-1,2,3,4-tetrahydrocarbazole monosuccinate monohydrate
• Empirical Formula (Hill Notation): C₁₄H₁₇N₃O · C₄H₆O₄ · H₂O
• CAS Number: 158930-17-7
• Molecular Weight: 379.41
• MDL number: MFCD18251278
• UNSPSC Code: 41116107
• PubChem Substance ID: 329749910
• NACRES: NA.24

Properties

• grade: pharmaceutical primary standard
• API family: frovatriptan
• manufacturer/tradename: USP
• application(s): pharmaceutical (small molecule)
• format: neat
• SMILES string: OC(CCC(O)=O)=O.NC(C(C=C1)=CC2=C1NC3=C2C[C@H](NC)CC3)=O.O
• InChI: 1S/C14H17N3O.C4H6O4.H2O/c1-16-9-3-5-13-11(7-9)10-6-8(14(15)18)2-4-12(10)17-13;5-3(6)1-2-4(7)8;/h2,4,6,9,16-17H,3,5,7H2,1H3,(H2,15,18);1-2H2,(H,5,6)(H,7,8);1H2/t9-;;/m1../s1
• InChI key: CUETXFMONOSVJA-KLQYNRQASA-N
• Gene Information: human ... HTR1B(3351), HTR1D(3352)

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Frovatriptan succinate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.

Biochem/physiol Actions

Frovatriptan is a serotonin 5HT-1B/1D-receptor agonist used to treat migraine. Frovatriptan has high affinity for the 5-HT(1B) and 5-HT(1D) receptors while affinity for 5-HT receptors other than 5-HT(1B/1D) is substantially lower with a pEC₅₀ value of 8.2 for the 5-HT1B receptor, compared to a pEC₅₀ value of 6.2 for the 5-HT7 receptor.

Frovatriptan is a serotonin 5HT-1B/1D-receptor agonist.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable