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About This Item
Empirical Formula (Hill Notation):
C15H10O5
CAS Number:
Molecular Weight:
270.24
Beilstein:
272179
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.79
Quality Level
Assay
≥95% (HPLC)
form
powder
color
yellow
mp
214-215 °C (lit.)
SMILES string
Oc1cc(O)c2C(=O)C(O)=C(Oc2c1)c3ccccc3
InChI
1S/C15H10O5/c16-9-6-10(17)12-11(7-9)20-15(14(19)13(12)18)8-4-2-1-3-5-8/h1-7,16-17,19H
InChI key
VCCRNZQBSJXYJD-UHFFFAOYSA-N
Gene Information
human ... ADORA2A(135), ADORA3(140), CYP1A2(1544)
rat ... Adora1(29290), Adora2a(25369)
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General description
Galangin is a flavonoid isolated from members of the Zingiberaceae family, which are mainly used for herbal medicines.
Application
Galangin has been used:
- as a test drug to test its ameliorative effect in a rodent model of cisplatin-induced nephrotoxicity
- to test its effect on the differentiation of 3T3-L1 preadipocyte cells into adipocytes
- as an internal standard in nuclear magnetic resonance spectroscopy and mass spectroscopy
Biochem/physiol Actions
Galangin exhibits antioxidant, anti-apoptotic, anti-inflammatory and anti-obesity properties. In addition, it also possesses anti-genotoxic activity against environmental and dietary carcinogens. Galangin inhibits cancer growth by hindering cancer cell proliferation, induction of apoptosis and autophagy and inhibition of metastasis. Galangin also has an ability to inhibit CYP1A1 (Cytochrome P450, family 1, member A1) activity.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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