SAB5200049

Monoclonal Anti-GABRB3 antibody produced in mouse

clone S87-25, 1 mg/mL, purified immunoglobulin

• Synonym(s): Anti-GABA(A) receptor subunit beta3, Anti-GABAAR Beta3, S87-25, Anti-Gabrb3
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: mouse
• Quality Level: 100
• conjugate: unconjugated
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: S87-25, monoclonal
• form: buffered aqueous glycerol solution
• mol wt: antigen predicted mol wt 55 kDa
• species reactivity: human, mouse, rat
• concentration: 1 mg/mL
• technique(s): immunocytochemistry: suitable; western blot: suitable
• isotype: IgG1
• NCBI accession no.: NP_032097.1
• UniProt accession no.: P28472
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: mouse ... Gabrb3(14402)

Description

General description

The γ-aminobutyric acid type A receptor β3 subunit (GABRB3) gene with nine exons spanning 250kb, is mapped to human chromosome 15q12, a hot region of genomic rearrangements. The gene codes for β3 subunit of GABAA receptor, which belongs to the GABA (γ-aminobutyric acid) receptor gene family.

Specificity

Detects ~55 kDa. No cross-reactivity against GABA-A-R-Beta 2 or –Beta1.

Immunogen

Fusion protein amino acids 370-433 of mouse GABA-A_r Beta3, Accession Number AAB60502.

Biochem/physiol Actions

γ-aminobutyric acid type A receptor β3 subunit (GABRB3) is a candidate gene for autism spectrum conditions (ASC). Alteration in the gene results in increased tactile sensitivity, or hypersensitivity. Overexpression of GABRB3 might be implicated in the pathogenesis of heroin dependence. Aberration or mutation of this gene leads to neurodevelopmental disorders, such as Angelman syndrome, Prader-Willi syndrome and schizophrenia. GABRB3 polymorphisms results in nonsyndromic cleft lip and/or palate (NSCL/P).

Features and Benefits

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Physical form

Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable