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SAB5702880

Sigma-Aldrich

Anti-MOV10 Antibody, clone 1M7M9, Rabbit Monoclonal

Synonym(s):

fSAP113, gb110

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₩391,790

₩391,790


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1 G
₩391,790

About This Item

UNSPSC Code:
12352203
NACRES:
NA.46

₩391,790


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biological source

rabbit

Quality Level

material

colorless

clone

1M7M9, monoclonal

form

liquid

mol wt

114 kDa

species reactivity

human, rat, rat

concentration

1.5 mg/mL

technique(s)

western blot: 1:500 - 1:2000

color

colorless

General description

5′ to 3′ RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3′ UTRs. Required for microRNA (miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC. Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2. Restricts retrotransposition of long interspersed element-1 (LINE-1 in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1. Facilitates LINE-1 uridylation by TUT4 and TUT7. Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskeletal mRNAs to influence neurite outgrowth in the cytosol (By similarity. May function as a messenger ribonucleoprotein (mRNP clearance factor. Exhibits antiviral activity against dengue virus (DENV.

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 800-900 of human MOV10 (Q9HCE1).
PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

Application

WB

Storage Class Code

10 - Combustible liquids

WGK

WGK 1


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A facile and efficient one-pot synthesis of thiochromans from bis (2-formylphenyl) disulfide and alkenols via iodine-promoted generation and subsequent intramolecular cycloaddition of< i> ortho</i>-thiobenzoquinone methides.
Tetrahedron Letters, 44(34), 6513-6517 (2003)

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