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SML3008

Sigma-Aldrich

SCIO-469

≥98% (HPLC)

Synonym(s):

2-(6-Chloro-5-((2R,5S)-4-(4-fluorobenzyl)-2,5-dimethylpiperazine-1-carbonyl)-1-methyl-1H-indol-3-yl)-N,N-dimethyl-2-oxoacetamide, 6-Chloro-5-[[(2R,5S)-4-[(4-fluorophenyl)methyl]-2,5-dimethyl-1-piperazinyl]carbonyl]-N,N,1-trimethyl-a-oxo-1H-indole-3-acetamide, SCIO 469, SCIO469, Scios 469, Scios-469, Scios469, Talmapimod

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100 μG
CA$442.00

About This Item

Empirical Formula (Hill Notation):
C27H30ClFN4O3
CAS Number:
309913-83-5
Molecular Weight:
513.00
MDL number:
MFCD11973651
UNSPSC Code:
12352200
NACRES:
NA.77

CA$442.00

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Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(C(C1=CN(C2=C1C=C(C(Cl)=C2)C(N3[C@@H](CN([C@H](C3)C)CC4=CC=C(C=C4)F)C)=O)C)=O)N(C)C

InChI

1S/C27H30ClFN4O3/c1-16-13-33(17(2)12-32(16)14-18-6-8-19(29)9-7-18)26(35)21-10-20-22(25(34)27(36)30(3)4)15-31(5)24(20)11-23(21)28/h6-11,15-17H,12-14H2,1-5H3/t16-,17+/m0/s1

InChI key

ZMELOYOKMZBMRB-DLBZAZTESA-N

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Corning® CoolRack® M30-PF, capacity 30 x 1.5 mL microfuge tubes, tapered wells for conical tubes, gray

CLS432048

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Corning® CoolRack® 500 ul M30-PF, capacity 30 x 500 ul microfuge tubes, tapered wells for conical tubes, gray

CLS432046

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Corning® CoolRack® M30, capacity 30 x 1.5 or 2 mL microfuge tubes, gray

CLS432041

Corning® CoolRack®

Corning® CoolRack® M30, capacity 30 x 1.5 or 2 mL microfuge tubes, green

CLS432042

Corning® CoolRack®

feature

Holds 30 x 1.5 mL tubes

feature

Holds 30 x 0.5 mL tubes

feature

wells 30, Holds 30 x 1.5-2 mL tubes

feature

wells 31, Holds 30 x 1.5-2 mL tubes

manufacturer/tradename

Corning 432048

manufacturer/tradename

Corning 432046

manufacturer/tradename

Corning 432041

manufacturer/tradename

Corning 432042

material

foamed PE

material

foamed PE

material

foamed PE

material

foamed PE

packaging

pkg of 1

packaging

pkg of 1

packaging

pkg of 1

packaging

pkg of 1

technique(s)

cryopreservation: suitable

technique(s)

cryopreservation: suitable

technique(s)

cryopreservation: suitable

technique(s)

cryopreservation: suitable

color

gray

color

gray

color

gray

color

green

Biochem/physiol Actions

Orally active, potent and selective mitogen-activated protein kinase (MAPK) p38alpha (p38α, MAPK14) inhibitor in vitro and in vivo.
SCIO-469 (Talmapimod) is an orally active, potent and selective mitogen-activated protein kinase (MAPK) p38alpha (p38α, MAPK14) inhibitor (IC50 = 9 nM; 10-fold over p38β, >2000-fold over 20 other kinases) with no significant affinity toward a panel of 70 enzymes and receptors. SCIO-469 inhibits multiple myeloma (MM) growth in mice in vivo (150 or 450 mg/kg powder diet; 5T2MM and 5T33MM) and augments proteasome inhibitor in a murine plasmacytoma model of MM (0.2 mg bortezomib/kg i.v. twice weekly with 30 mg SCIO-469/kg b.i.d. p.o.; RPMI8226).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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    Sebastien M Weyn-Vanhentenryck et al.
    Nature communications, 9(1), 2189-2189 (2018-06-08)
    Alternative splicing (AS) is one crucial step of gene expression that must be tightly regulated during neurodevelopment. However, the precise timing of developmental splicing switches and the underlying regulatory mechanisms are poorly understood. Here we systematically analyze the temporal regulation
    Brie Wamsley et al.
    Neuron, 100(4), 846-859 (2018-10-16)
    Cortical interneurons display a remarkable diversity in their morphology, physiological properties, and connectivity. Elucidating the molecular determinants underlying this heterogeneity is essential for understanding interneuron development and function. We discovered that alternative splicing differentially regulates the integration of somatostatin- and

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