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SRP5295

Sigma-Aldrich

PI3K (p110-β/p85-β), active, His tagged human

PRECISIO®, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym(s):

p110-beta, p85-beta

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6 X 500 G
CA$6,110.00
12 X 500 G
CA$12,210.00

About This Item

CAS Number:
UNSPSC Code:
12352200
NACRES:
NA.32

CA$6,110.00


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biological source

human

recombinant

expressed in baculovirus infected Sf9 cells

product line

PRECISIO®

Assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

specific activity

22.4-33.6 nmol/min·mg

mol wt

~111 kDa (p110β)
~88 kDa (p85β)

NCBI accession no.

application(s)

cell analysis

shipped in

dry ice

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This Item
SRP5319SRP5280SRP0233
assay

≥70% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

assay

≥80% (SDS-PAGE)

Gene Information

human ... PIK3CB(5291)

Gene Information

human ... PIK3CA(5290)

Gene Information

mouse ... Pik3ca(18706)

Gene Information

human ... PIK3CA(5290)

biological source

human

biological source

-

biological source

human, mouse

biological source

human

specific activity

22.4-33.6 nmol/min·mg

specific activity

11.2-16.8 nmol/min·mg

specific activity

64-97 nmol/min·mg

specific activity

≥13 pmol/min-μg

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

form

aqueous solution

application(s)

cell analysis

application(s)

-

application(s)

cell analysis

application(s)

life science and biopharma

General description

PI3K phosphorylate the 3-prime OH position of the inositol ring of inositol lipids which functions in signaling pathways that regulate cell growth by virtue of their activation in response to various mitogenic stimuli. PI3Ks are composed of a 110-kDa catalytic subunit and a 85-kDa adaptor subunit. PI3K plays a critical role in regulating the formation and stability of alpha-2B-beta-3 integrin adhesion bonds, which are necessary for shear force-induced platelet activation. PI3K sustains alpha-2B-beta-3 integrin activation and stabilized platelet aggregation by regulating both integrin-dependent calcium flux and Gi activation of RAP1B.

Physical form

Supplied in 50 mM sodium phosphate, pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.2 mM DTT, 25% glycerol.

Preparation Note

After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.

Legal Information

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Health hazardExclamation mark

Signal Word

Danger

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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