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WH0009588M1

Sigma-Aldrich

Monoclonal Anti-PRDX6 antibody produced in mouse

clone 3A10-2A11, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-1Cys, Anti-AOP2, Anti-KIAA0106, Anti-MGC46173, Anti-NSGPx, Anti-PRX, Anti-aiPLA2, Anti-p29, Anti-peroxiredoxin 6

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1 EA
CA$114.00

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

CA$114.00

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biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

3A10-2A11, monoclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

indirect ELISA: suitable
western blot: 1-5 μg/mL

isotype

IgG1κ

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1 of 4

This Item
WH0007001M1WH0025824M1SAB1404163
Monoclonal Anti-PRDX6 antibody produced in mouse clone 3A10-2A11, purified immunoglobulin, buffered aqueous solution

WH0009588M1

Monoclonal Anti-PRDX6 antibody produced in mouse

Monoclonal Anti-PRDX2 antibody produced in mouse clone 4E10-2D2, purified immunoglobulin, buffered aqueous solution

WH0007001M1

Monoclonal Anti-PRDX2 antibody produced in mouse

Monoclonal Anti-PRDX5 antibody produced in mouse clone 3E6, purified immunoglobulin, buffered aqueous solution

WH0025824M1

Monoclonal Anti-PRDX5 antibody produced in mouse

Monoclonal Anti-PRDX1 antibody produced in mouse clone 4B11-D10, purified immunoglobulin, buffered aqueous solution

SAB1404163

Monoclonal Anti-PRDX1 antibody produced in mouse

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

biological source

mouse

biological source

mouse

biological source

mouse

biological source

mouse

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

clone

3A10-2A11, monoclonal

clone

4E10-2D2, monoclonal

clone

3E6, monoclonal

clone

4B11-D10, monoclonal

Gene Information

human ... PRDX6(9588)

Gene Information

human ... PRDX2(7001)

Gene Information

human ... PRDX5(25824)

Gene Information

human ... PRDX1(5052)

species reactivity

human

species reactivity

human

species reactivity

human

species reactivity

human

General description

Peroxiredoxin 6 (Prdx6) is a non-seleno peroxidase enzyme, encoded by the gene mapped to human chromosome 1q25.1. Prdx6 belongs to thiol-specific antioxidant protein family. It is highly expressed in lung, alveolar epithelial type II cells and alveolar macrophages. The protein is characterized with a single conserved cysteine residue and is called 1-Cys Prdx. Prdx6 contains 224 amino acids.

Immunogen

PRDX6 (AAH35857.1, 1 a.a. ~ 224 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
MPGGLLLGDVAPNFEANTTVGRIRFHDFLGDSWGILFSHPRDFTPVCTTELGRAAKLAPEFAKRNVKLIALSIDSVEDHLAWSKDINAYNCEEPTEKLPFPIIDDRNRELAILLGMLDPAEKDEKGMPVTARVVFVFGPDKKLKLSILYPATTGRNFDEILRVVISLQLTAEKRVATPVDWKDGDSVMVLPTIPEEEAKKLFPKGVFTKELPSGKKYLRYTPQP

Biochem/physiol Actions

Peroxiredoxin 6 (Prdx6) is a bifunctional enzyme, carrying out both phospholipase A2 (PLA2) activity and glutathione (GSH) peroxidase function. The encoded protein aids in redox regulation of the cell and is implicated in reduction of H2O2 and short chain organic, fatty acid, and phospholipid hydroperoxides. It might also have a crucial role in the regulation of phospholipid turnover and in antioxidant defense. Prdx6 is highly expressed at leading edges of wounds and aids in wound healing. Deficiency of the enzyme activity is observed in cataracts of the lens. Overexpression of Prdx6 leads to several degenerative CNS (central nervous system) disorders such as Alzheimer′s, Parkinson′s, Pick′s, and Crutzfeld-Jakob diseases and schizophrenia. In addition, elevated expression of the enzyme is also observed in various neoplastic diseases including malignant mesothelioma, bronchogenic squamous cell carcinoma and cancer of the gingivo-buccal area, bladder and breast.

Physical form

Solution in phosphate buffered saline, pH 7.4

Legal Information

GenBank is a registered trademark of United States Department of Health and Human Services

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves
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    Lot/Batch Number
    08018-S1

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    J W Macadam et al.
    Plant physiology, 99(3), 872-878 (1992-07-01)
    Cessation of cell expansion has been associated with cell wall cross-linking reactions catalyzed by peroxidase. This study utilized two genotypes of tall fescue (Festuca arundinacea Schreb.) that differ in length of the leaf elongation zone to investigate the relationship between
    Chuan Chiang-Ni et al.
    Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi, 49(6), 837-842 (2015-02-05)
    The phenotypic heterogeneity of the human pathogen Streptococcus pyogenes [group A streptococcus (GAS)] is associated with bacterial virulence variation. During invasive GAS infection, mutations in the two-component regulatory system covR/covS leads to increases in hyaluronic acid capsule production, virulence genes
    S M Mallison et al.
    Infection and immunity, 56(4), 823-830 (1988-04-01)
    In vitro experimentation indicates that periodontitis-associated bacteria contain potent polyclonal B-cell activators (PBA). We reasoned that if PBA were operative in vivo, plasma cells specific for nonoral antigens should be present in the inflamed gingival tissues, which are characterized by
    W E Bullock et al.
    The Journal of experimental medicine, 165(1), 195-210 (1987-01-01)
    The principal host cell of H. capsulatum (Hc) is the M phi within which the pathogenic yeast phase of the fungus multiplies during active disease. The initial interaction between Hc yeasts and M phi therefore is a crucial step in
    Nancy J Sullivan et al.
    Journal of virology, 79(1), 547-553 (2004-12-15)
    Ebola virus infection causes a highly lethal hemorrhagic fever syndrome associated with profound immunosuppression through its ability to induce widespread inflammation and cellular damage. Though GP, the viral envelope glycoprotein, mediates many of these effects, the molecular events that underlie
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