Microwave and flow syntheses of Pseudomonas quinolone signal (PQS) and analogues.

Microwave and flow syntheses of Pseudomonas quinolone signal (PQS) and analogues.

Organic & biomolecular chemistry (2010-10-23)

James T Hodgkinson, Warren R J D Galloway, Shreya Saraf, Ian R Baxendale, Steven V Ley, Mark Ladlow, Martin Welch, David R Spring

ABSTRACT

Expedient syntheses of Pseudomonas quinolone signal (PQS) and related structural analogues using microwave and flow methods are reported.

MATERIALS

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2-Chloro-N-methoxy-N-methylacetamide, 98%

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