184225

Hydrogen fluoride pyridine

pyridine ~30 %, hydrogen fluoride ~70 %

• 동의어(들): HF-Pyridine, Olah′s reagent, PPHF, Poly(pyridine fluoride), Pyridine hydrofluoride, Pyridinium poly(hydrogen fluoride), Pyridinium polybifluoride
• CAS Number: 62778-11-4
• Beilstein: 4750151
• MDL number: MFCD00012436
• UNSPSC 코드: 12352301
• PubChem Substance ID: 24851101
• NACRES: NA.22

속성

• 양식: liquid
• Quality Level: 200
• 구성: hydrogen fluoride, ~70% ; pyridine, ~30%
• density: 1.1 g/mL at 20 °C (lit.)
• 저장 온도: −20°C
• SMILES string: F[H].c1ccncc1
• InChI: 1S/C5H5N.FH/c1-2-4-6-5-3-1;/h1-5H;1H
• InChI key: GRJJQCWNZGRKAU-UHFFFAOYSA-N

설명

일반 설명

May contain or form low levels of calcium fluoride during storage. Presence of this does not impact the specification values.

애플리케이션

Convenient form of anhydrous HF, stable up to 50°C. Has been used for the preparation of β-fluoroamines from amino alcohols and for the fluorination of acetylenes.
Used together with hypervalent iodine(III) reagents for ipso-fluorination of para-substituted phenols providing cyclohexadienones. Employed with Selectfluor^® (Catalog No. 439479) for geminal fluorination of 2,2-diaryl-1,3-dithiolanes.

Reactant for preparation of:

• Epimers of shikimic acid with the features of fucosylated glycans via zinc-mediated reductive ring opening followed by a Barbier reaction
• Vaccinia H1-related (VHR) phosphatase inhibitor with a nonacidic phosphate-mimicking core structure
• Candidates for nucleic acid drugs
• ω-substituted gem-difluoroalkanes by oxidative desulfurization-difluorination

Reagent for:

• Halofluorination reactions

법적 정보

Selectfluor is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS06,GHS05
• 신호어: Danger
• 유해 및 위험 성명서: H300 + H310 + H330,H314
• 예방조치 성명서: P260 - P270 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Eye Dam. 1 - Skin Corr. 1A
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter