191140

7-Aminocephalosporanic acid

98%

• 동의어(들): 7-ACA
• 실험식(Hill 표기법): C₁₀H₁₂N₂O₅S
• CAS Number: 957-68-6
• Molecular Weight: 272.28
• Beilstein: 622637
• EC Number: 213-485-0
• MDL number: MFCD00005177
• UNSPSC 코드: 12352106
• PubChem Substance ID: 24851470
• NACRES: NA.22

속성

• Quality Level: 200
• 분석: 98%
• 양식: powder
• 광학 활성: [α]19/D +90°, c = 0.5 in KH₂PO₄/trace NaOH
• 반응 적합성: reaction type: solution phase peptide synthesis
• mp: >300 °C (lit.)
• 항생제 활성 스펙트럼: Gram-positive bacteria
• 응용 분야: peptide synthesis
• 동작 모드: cell wall synthesis | interferes
• 저장 온도: 2-8°C
• SMILES string: [H][C@]12SCC(COC(C)=O)=C(N1C(=O)[C@H]2N)C(O)=O
• InChI: 1S/C10H12N2O5S/c1-4(13)17-2-5-3-18-9-6(11)8(14)12(9)7(5)10(15)16/h6,9H,2-3,11H2,1H3,(H,15,16)/t6-,9-/m1/s1
• InChI key: HSHGZXNAXBPPDL-HZGVNTEJSA-N

설명

일반 설명

Chemical structure: ß-lactam

애플리케이션

7-Aminocephalosporanic acid (7-ACA) can be used as a starting material to synthesize:

• Cefotaxime by acylation reaction with S-benzothiazol-2-yl(2-amino-4-thiazolyl)(methoxyimino)thioacetate (MAEM) in the presence of triethylamine.
• Cefpodoxime proxetil, a third-generation antibiotic via cefotaxime intermediate.
• Sodium 3′-substituted cephalosporanate sulfone derivatives as potential inhibitors of β-lactamase.

Potent inhibitor of bacterial (S. aureus) β-lactamase.

안전성 정보

• 픽토그램: GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H317,H334
• 예방조치 성명서: P261 - P272 - P280 - P284 - P302 + P352 - P333 + P313
• Hazard Classifications: Resp. Sens. 1 - Skin Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Faceshields, Gloves