226351

N-Hydroxymaleimide

97%, for peptide synthesis

• 동의어(들): 1-Hydroxypyrrole-2,5-dione
• 실험식(Hill 표기법): C₄H₃NO₃
• CAS Number: 4814-74-8
• Molecular Weight: 113.07
• Beilstein: 1524594
• EC Number: 225-385-4
• MDL number: MFCD00005501
• UNSPSC 코드: 12352005
• PubChem Substance ID: 24853562
• NACRES: NA.22

속성

• Product Name: N-Hydroxymaleimide, 97%
• Quality Level: 200
• 분석: 97%
• 양식: solid
• 반응 적합성: reaction type: Addition Reactions
• mp: 130-133 °C (dec.) (lit.)
• 응용 분야: peptide synthesis
• 작용기: imide; maleimide
• SMILES string: ON1C(=O)C=CC1=O
• InChI: 1S/C4H3NO3/c6-3-1-2-4(7)5(3)8/h1-2,8H
• InChI key: BUXKULRFRATXSI-UHFFFAOYSA-N

설명

일반 설명

N-Hydroxymaleimide (NHMI) is an organic compound that is widely used as an oxidizing agent in organic synthesis. It is frequently used to selectively oxidize thiols to disulfides and in the synthesis of α, β-unsaturated carbonyl compounds. It can also act as a Michael acceptor and is used in the synthesis of peptides and proteins.

애플리케이션

N-Hydroxymaleimide can be used as an oxidant to generate N-hydroxy anilines in situ, which serve as key intermediates in the selective coupling reaction of N-substituted anilines with hydroxylamine derivatives, for the efficient synthesis of aromatic oximes.

안전성 정보

• 픽토그램: GHS05
• 신호어: Danger
• 유해 및 위험 성명서: H314
• 예방조치 성명서: P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363
• Hazard Classifications: Eye Dam. 1 - Skin Corr. 1B
• Storage Class Code: 8A - Combustible corrosive hazardous materials
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges