Name: Diethyl pyrocarbonate
Brand: ALDRICH

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About This Item

Linear Formula:

O(COOC₂H₅)₂

CAS Number:

1609-47-8

Molecular Weight:

162.14

Beilstein:

637031

EC Number:

216-542-8

MDL number:

MFCD00009106

UNSPSC 코드:

12352100

PubChem Substance ID:

24865430

NACRES:

NA.22

기술 서비스

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도움 문의

Quality Level

200

분석

96% (NT)

양식

liquid

색상

APHA: ≤20

refractive index

n20/D 1.398 (lit.)
n20/D 1.398

bp

93-94 °C/18 mmHg (lit.)

solubility

95% ethanol: 4.5 g/10 mL, clear, colorless

density

1.121 g/mL at 20 °C
1.101 g/mL at 25 °C (lit.)

작용기

carbonate

배송 상태

wet ice

저장 온도

2-8°C

SMILES string

CCOC(=O)OC(=O)OCC

InChI

1S/C6H10O5/c1-3-9-5(7)11-6(8)10-4-2/h3-4H2,1-2H3

InChI key

FFYPMLJYZAEMQB-UHFFFAOYSA-N

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일반 설명

Diethyl pyrocarbonate (DEP) is a bactericidal agent and decomposes in water to CO₂ and ethanol. DEP inhibits enzymes such as DNase and RNase without affecting nucleic acids. It is useful for the preparation of mRNA from tissues.

애플리케이션

Diethyl pyrocarbonate may be used in the following studies:

For the modification of histidyl residues in proteins.
As a nuclease inhibitor, for the extraction of undegraded nucleic acids from etiolated and green plant tissues.
For the modification of linear and supercoiled plasmid DNAs.
As a chemical probe to investigate the secondary structure in negatively supercoiled DNA.
For cabethoxylation of histidine residues of actin.

Modification reagent for His and Tyr residues in proteins. Robust probe for structural disruptions in dsDNA, reacting with fully or partially unstacked bases.