707066

DCA Deblock (0.36M dichloroacetic acid in toluene)

• 동의어(들): DCA Deblock, DEBLOCK (0.36M dichloroacetic acid in toluene)
• 실험식(Hill 표기법): C₂H₂Cl₂O₂
• CAS Number: 79-43-6
• Molecular Weight: 128.94
• MDL number: MFCD00004223
• UNSPSC 코드: 12352106
• PubChem Substance ID: 329762686

속성

• 양식: liquid
• Quality Level: 100
• 농도: ≤100 ppm in H₂O
• bp: 110-111 °C
• density: 0.884 g/mL at 25 °C
• SMILES string: OC(=O)C(Cl)Cl
• InChI: 1S/C2H2Cl2O2/c3-1(4)2(5)6/h1H,(H,5,6)
• InChI key: JXTHNDFMNIQAHM-UHFFFAOYSA-N

설명

일반 설명

Deblock solution, containing dichloroacetic acid (DCA) in dichloromethane or Toluene, removes the dimethoxytrityl (DMT) protecting the group from the 5′ hydroxyl moiety of nucleotides already incorporated into the growing nucleic acid, prior to the addition of the next phosphoramidite. Removal of the DMT allows the unprotected 5′ hydroxyl moiety to react with a new phosphoramidite in a subsequent extension reaction.

애플리케이션

DCA Deblock (0.36M dichloroacetic acid in toluene) is suitable for the removal of 4,4Adimethoxytrityl (DMTr) protecting groups for the synthesis of antisense oligonucleotides in high yield and purity.

안전성 정보

• 픽토그램: GHS02,GHS08,GHS05,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H225,H304,H315,H318,H336,H351,H360FD,H362,H373,H412
• 예방조치 성명서: P210 - P263 - P280 - P301 + P310 - P305 + P351 + P338 - P331
• Hazard Classifications: Aquatic Chronic 3 - Asp. Tox. 1 - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Lact. - Repr. 1B - Skin Irrit. 2 - STOT RE 2 Inhalation - STOT SE 3
• 표적 기관: Central nervous system
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 3
• Flash Point (°F): 41.0 °F
• Flash Point (°C): 5 °C
• 개인 보호 장비: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter