764817

Poly(lactide-co-glycolide)-block-poly(ethylene glycol)-block-poly(lactide-co-glycolide)

average M_n (1100-1000-1100), lactide:glycolide 75:25

• 동의어(들): PLGA-PEG-PLGA
• UNSPSC 코드: 12162002
• NACRES: NA.23

속성

• 설명: typical PEG PDI<1.1; overall PDI≤2.0 (THF, PS)
• Quality Level: 100
• 양식: semisolid
• 피드(feed) 비율: lactide:glycolide 75:25
• 분자량: PEG average M_n 1,000; PLGA average M_n 2,200; average M_n (1100-1000-1100)
• 분해 기간: 2-3 weeks
• 전이 온도: T_m 230-235 °C
• PDI: <2.0
• 저장 온도: 2-8°C

설명

일반 설명

PLGA-PEG-PLGA is an amphiphilic triblock copolymer which can self-assemble into micelles in aqueous medium due to the hydrophobic interactions present in the hydrophobic segments. The PEG segment imparts hydrophilicity and improves the biocompatibility of the copolymer. The PLGA segment forms a hydrophobic core and can solubilize hydrophobic drugs. These copolymers are widely used as nanocarriers for the sustained release of drugs.

애플리케이션

Used in the synthesis of targeted nanoparticles which are used for differential delivery and controlled release of drugs.

특징 및 장점

Biocompatible, degradable, thermosensitive, high stability, small size (<200 nm) and properties can be easily modified.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable