902675

BocNH-PEG₆-acid

• 동의어(들): 2,2-Dimethyl-4-oxo-3,8,11,14,17,20,23-heptaoxa-5-azapentacosan-25-oic acid, Boc-NH-PEG6-CH₂COOH
• 실험식(Hill 표기법): C₁₉H₃₇NO₁₀
• CAS Number: 391684-36-9
• Molecular Weight: 439.50
• MDL number: MFCD30489670
• UNSPSC 코드: 12352106
• NACRES: NA.22

속성

• 양식: liquid
• 반응 적합성: reagent type: linker
• refractive index: n/D 1.4657
• 작용기: Boc; amine; carboxylic acid
• 저장 온도: −20°C
• SMILES string: OC(COCCOCCOCCOCCOCCOCCNC(OC(C)(C)C)=O)=O
• InChI: 1S/C19H37NO10/c1-19(2,3)30-18(23)20-4-5-24-6-7-25-8-9-26-10-11-27-12-13-28-14-15-29-16-17(21)22/h4-16H2,1-3H3,(H,20,23)(H,21,22)
• InChI key: ZKCDWMFMVAYYED-UHFFFAOYSA-N

설명

애플리케이션

This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and Boc-protected amino group at the other, which can be deprotected with mildly acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. BocNH-PEG₆-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

기타 정보

α_vβ₃ Integrin-Targeting Arg-Gly-Asp (RGD) Peptidomimetics Containing Oligoethylene Glycol

Ultrasmall particle of iron oxide-RGD peptidomimetic conjugate: synthesis and characterization

법적 정보

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable