930458

OxMet2-alkyne

• 동의어(들): (3-Phenyl-1,2-oxaziridin-2-yl)(4-(prop-2-yn-1-yloxy)piperidin-1-yl)methanone
• 실험식(Hill 표기법): C₁₆H₁₈N₂O₃
• Molecular Weight: 286.33
• MDL number: MFCD34704579
• UNSPSC 코드: 12352101
• NACRES: NA.22

속성

• 설명: Application: Chemoproteomics
• Quality Level: 100
• 양식: liquid
• 저장 온도: −20°C
• SMILES string: O=C(N1OC1C2=CC=CC=C2)N(CC3)CCC3OCC#C
• InChI key: ZAZCIGLVVPPSLS-UHFFFAOYSA-N

설명

애플리케이션

OxMet2-alkyne is an oxaziridine probe that can be used to label methionines. A method was developed using cysteine-reactive compounds including this one to allow for unbiased analysis of proteomic data in quantitative applications (Zanon et al. 2021). The method uses light or heavy labelling with the isotopically labelled desthiobiotin azide (isoDTB) tag for mass spectrometry analysis (Zanon et al. 2020). Analysis then uses the isotopic tandem orthogonal proteolysis activity-based protein profiling (isoTOP-ABPP) workflow (Weerapana et al. 2010, Backus et al. 2016)

기타 정보

Profiling the proteome-wide selectivity of diverse electrophiles

A quantitative thiol reactivity profiling platform to analyze redox and electrophile reactive cysteine proteomes

Ethynylation of Cysteine Residues: From Peptides to Proteins in Vitro and in Living Cells

A Chemoproteomic Platform To Assess Bioactivation Potential of Drugs

Inhibition of Zinc-Dependent Histone Deacetylases with a Chemically Triggered Electrophile

Reversibility of Covalent Electrophile-Protein Adducts and Chemical Toxicity

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable