857390P

W146

(R)-3-Amino-(3-hexylphenylamino)-4-oxobutylphosphonic acid (TFA salt), powder

• 동의어(들): S1P1 Antagonist
• 실험식(Hill 표기법): C₁₈H₂₈F₃N₂O₆P
• CAS Number: 909725-62-8
• Molecular Weight: 456.39
• MDL number: MFCD00036905
• UNSPSC 코드: 12352211
• NACRES: NA.25

속성

• 분석: >99% (TLC)
• 양식: powder
• 포장: pkg of 1 × 1 mg (857390P-1mg); pkg of 1 × 10 mg (857390P-10mg)
• 제조업체/상표: Avanti Research^™ - A Croda Brand 857390P
• 지질 유형: sphingolipids
• 배송 상태: dry ice
• 저장 온도: −20°C

설명

일반 설명

Compound 2a is a selective antagonist for human S1P1 (hS1P1) receptor activation by the physiological agonist S1P.

W146 is a sphingosine-1-phosphate 1 (S1P1) selective antagonist.

애플리케이션

W146 has been used:

• to verify the mode of action of sphingosine-1-phosphate (S1P) in human bone marrow derived mesenchymal stem cells (hMSCs ) and primary human hepatogenic profibrotic cells (hHPCs)
• to study oxidative stress and drug treatment in granulosa cells
• to evaluate its effects on transendothelial electrical resistance (TEER)

생화학적/생리학적 작용

W146 acts as an orthosteric antagonist. It is linked to blood lymphopenia and lung edema in mice.

포장

5 mL Amber Glass Screw Cap Vial (857390P-10mg)

5 mL Amber Glass Screw Cap Vial (857390P-1mg)

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): No data available
• Flash Point (°C): No data available