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About This Item
실험식(Hill 표기법):
C38H70N4O2· 3HCl
CAS Number:
Molecular Weight:
724.37
UNSPSC 코드:
12352211
NACRES:
NA.25
양식
powder
포장
pkg of 1 × 5 mg (890893P-5mg)
제조업체/상표
Avanti Research™ - A Croda Brand
지질 유형
transfection
cationic lipids
배송 상태
dry ice
저장 온도
−20°C
SMILES string
CC1(CC[C@H](OC(N(CCCN)CCCCNCCCN)=O)C2)C2=CCC3C1CCC4(C)C3CCC4C(CCCC(C)C)C
InChI
1S/C38H70N4O2/c1-28(2)11-8-12-29(3)33-15-16-34-32-14-13-30-27-31(17-19-37(30,4)35(32)18-20-38(33,34)5)44-36(43)42(26-10-22-40)25-7-6-23-41-24-9-21-39/h13,28-29,31-35,41H,6-12,14-27,39-40H2,1-5H3/t29?,31-,32?,33?,34?,35?,37?,38?/m0/s1
InChI key
KBBLYWGVXTZWCU-JPEXWTJSSA-N
일반 설명
N4-Cholesteryl-Spermine (GL67) comprises of the cationic lipid GL67 with spermine and cholesterol.
애플리케이션
- GL67 lipid-based liposomal formulation for efficient siRNA delivery into human lung cancer cells.: This study explores the use of GL67 liposomes for delivering siRNA to human lung cancer cells, highlighting its potential for targeted cancer therapies (Jarallah et al., 2023).
- Aerosol-Mediated Non-Viral Lung Gene Therapy: The Potential of Aminoglycoside-Based Cationic Liposomes.: The research focuses on the efficacy of GL67 liposomes in aerosol form for non-viral gene therapy in the lungs, demonstrating significant gene transfer efficiency (Le Gall et al., 2021).
- Low-frequency ultrasound increases non-viral gene transfer to the mouse lung.: The study investigates the enhancement of GL67-mediated gene transfer using low-frequency ultrasound, showing improved transfection in mouse lungs (Xenariou et al., 2010).
생화학적/생리학적 작용
N4-Cholesteryl-Spermine (GL67) in combination with DOPE (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine) and DMPE-PEG5000 (1,2-Dimyristoyl-sn-Glycero-3-Phosphoethanolamine-N-[methoxy (Polyethylene glycol)5000] is used as a non-viral gene transfer agent.
포장
5 mL Amber Glass Screw Cap Vial (890893P-5mg)
법적 정보
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
No data available
Flash Point (°C)
No data available
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