Name: Neurotensin
Brand: MM

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About This Item

실험식(Hill 표기법):

C₇₈H₁₂₁N₂₁O₂₀

CAS Number:

39379-15-2

Molecular Weight:

1672.92

MDL number:

MFCD00080064

UNSPSC 코드:

12352202

NACRES:

NA.77

기술 서비스

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도움 문의

Quality Level

100

분석

≥97% (HPLC)

양식

lyophilized solid

제조업체/상표

Calbiochem^®

저장 조건

OK to freeze
desiccated (hygroscopic)

색상

white to off-white

solubility

5% acetic acid: 1 mg/mL

배송 상태

ambient

저장 온도

−20°C

SMILES string

N3(C(CCC3)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCCN=C(N)N)C(=O)N4C(CCC4)C(=O)NC(Cc5ccc(cc5)O)C(=O)NC(C(CC)C)C(=O)NC(CC(C)C)C(=O)O)C(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C2NC(=O)CC2)CC(C)C)Cc1ccc(cc1)O)CCC(=O)O)CC(=O)N)CCCCN

InChI

1S/C78H121N21O20/c1-7-43(6)63(73(115)96-57(76(118)119)37-42(4)5)97-70(112)55(39-45-21-25-47(101)26-22-45)95-72(114)59-18-13-35-99(59)75(117)52(16-11-33-86-78(83)84)90-64(106)48(15-10-32-85-77(81)82)89-71(113)58-17-12-34-98(58)74(116)51(14-8-9-31-79)91-69(111)56(40-60(80)102)94-66(108)50(28-30-62(104)105)88-68(110)54(38-44-19-23-46(100)24-20-44)93-67(109)53(36-41(2)3)92-65(107)49-27-29-61(103)87-49/h19-26,41-43,48-59,63,100-101H,7-18,27-40,79H2,1-6H3,(H2,80,102)(H,87,103)(H,88,110)(H,89,113)(H,90,106)(H,91,111)(H,92,107)(H,93,109)(H,94,108)(H,95,114)(H,96,115)(H,97,112)(H,104,105)(H,118,119)(H4,81,82,85)(H4,83,84,86)

InChI key

PCJGZPGTCUMMOT-UHFFFAOYSA-N

일반 설명

Neurotensin (NT), a 13-amino acid peptide neurotransmitter encoded by the NTS gene. NT is located in the gastrointestinal tract and heterogeneously distributed in the mammalian central nervous system, and has many neurotransmitter-like characteristics. It influences various central and peripheral functions by interacting with three neurotensin receptors. It is linked to the modulation of dopaminergic systems and in the induction of changes in behavior, muscle relaxation, nociception, and hypothermia, as well as appetite, learning, memory, and fat metabolism. Moreover, it is a modulator of noradrenergic activity. It also acts as an endogenous anti-psychotic compound and lowers blood pressure, increases vascular permeability, and increases plasma levels of glucagon, glucose, growth hormone, and prolactin in rats. Additionally, it regulates the release of pituitary hormones from the brain and insulin, glucagon, and somatostatin from the gut.

생화학적/생리학적 작용

Cell permeable: no

Primary Target
Modulator of noradrenergic activity

Product does not compete with ATP.

Reversible: no

포장

Yes

경고

Toxicity: Standard Handling (A)

서열

Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH

기타 정보

Kinkead, B., et al. 1999. Biol. Psychiatr.46, 340.
Tyler, B.M., et al. 1998. Brain Res. 792, 246.
Tsuda, K., and Masuyuma, Y. 1993. Am. J. Hypertens. 6, 473.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)