This ready-to-use product, OSTEOSOFT^® - mild decalcifier-solution for histology, has been specifically developed for human cell diagnostics in humans and is used for the demineralization and decalcification of bones, punched bone-marrow specimens, and other hard tissue of human origin.
Decalcification is necessary for optical microscopic examinations of hard tissue in routine histological procedures. For the decalcification of sensitive, calcium-containing tissues, such as iliac crest biopsies, OSTEOSOFT^® can be used. Its formulation is based on EDTA. Its pendant, OSTEOMOLL^®(Product number 1.01736), can be used for the decalcification of hard tissue such as teeth and bone as its formulation is based on formaldehyde and acetic acid. The amount of OSTEOSOFT^®needed is dependent upon on the size, type and thickness of the material. Both solutions are color-coded, to distinguish them from each other, fixatives and solvents used in the histological laboratory. OSTEOSOFT^® is color-coded yellow, OSTEOMOLL^® is color-coded blue. Whereby OSTEOSOFT^® preserves the antigen structures in the tissue, thus, an IHC analysis can be performed, OSTEOMOLL^® will be used for tissues that are not destined for antibody analysis.
Both decalcifiers can be used for clinical diagnostic purposes and in laboratory accreditation processes as they are certified and registered as IVD and CE product. OSTEOSOFT^® is used only once and fresh solution must be used for each tissue. The quantity of OSTEOSOFT^® required is dependent on the size, type, and density of the respective material. For more details, please see instructions for use (IFU). The IFU can be downloaded from this webpage.

OSTEOMOLL is a registered trademark of Merck KGaA, Darmstadt, Germany

OSTEOSOFT is a registered trademark of Merck KGaA, Darmstadt, Germany