521233

PDGFR Tyrosine Kinase Inhibitor IV

• 동의어(들): PDGFR Tyrosine Kinase Inhibitor IV, 3-Fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine, JNJ-10198409
• 실험식(Hill 표기법): C₁₈H₁₆FN₃O₂
• CAS Number: 627518-40-5
• Molecular Weight: 325.34
• MDL number: MFCD11045292
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• Quality Level: 100
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: off-white
• solubility: DMSO: 10 mg/mL; methanol: 5 mg/mL
• 배송 상태: ambient
• 저장 온도: −20°C
• SMILES string: Fc1cc(ccc1)Nc2[nH]nc3c2Cc4c3cc(c(c4)OC)OC
• InChI: 1S/C18H16FN3O2/c1-23-15-7-10-6-14-17(13(10)9-16(15)24-2)21-22-18(14)20-12-5-3-4-11(19)8-12/h3-5,7-9H,6H2,1-2H3,(H2,20,21,22)
• InChI key: ZDNURMVOKAERHZ-UHFFFAOYSA-N

설명

일반 설명

A cell-permeable indenopyrazole compound that displays potent antiproliferative properties in several human tumor cell lines (IC₅₀<33 nM). Shown to act as an ATP-competitive and reversible inhibitor of PDGFR (IC₅₀ = 4.2 nM and 45 nM for -β and -α, respectively) and c-Abl (IC₅₀ = 22 nM). Exhibits less activity towards Lck, c-Src, and Fyn (IC₅₀ = 100 nM, 185 nM and 378 nM, respectively) and exhibits little or no inhibition toward VEGFR, HER-2, Cdk′s-1,-2,-4 &-7, bFGFR-1 and EGFR (IC₅₀ = 3.1 µM, >10 µM, >10 µM, 45.8 µM and >100 µM, respectively).

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
PDGFR Tyrosine Kinase

Product competes with ATP.

Reversible: yes

Target IC₅₀: 4.2 nM and 45 nM for -β and -α form of PDGFR, respectively

포장

Packaged under inert gas

경고

Toxicity: Harmful (C)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Ho, C.Y., et al. 2005. J. Med. Chem.48, 8163.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3