566661

SAG

≥95% (HPLC), liquid, smoothened agonist, Calbiochem^®

• 동의어(들): InSolution Smoothened Agonist, SAG, SAG _1.3 in Solution, SAG_1.3 in Solution
• 실험식(Hill 표기법): C₂₈H₂₈ClN₃OS · 2HCl · xH₂O
• Molecular Weight: 562.98 (anhydrous basis)
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Product Name: Smoothened Agonist, SAG, InSolution, ≥95%, 10 mM aqueous solution
• Quality Level: 100
• 분석: ≥95% (HPLC)
• 양식: liquid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 배송 상태: wet ice
• 저장 온도: −20°C

설명

일반 설명

A cell-permeable benzothiophene compound that modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (K_D = 59 nM). Shown to induce Hedgehog pathway activation (EC₅₀ ∼3 nM in NIH 3T3-derived Shh-LIGHT2 cells) and counteracts Cyclopamine-KAAD (Cat. No. 239804) inhibition of Smo. Reported to act as an activator at low concentrations and as an inhibitor at very high concentrations.

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

물리적 형태

A 10 mM (500 µg/86 µl) solution of Smoothened Agonist, SAG (Cat. No. 566660) in H₂O.

재구성

Following initial thaw, aliquot and freeze (-20°C).

기타 정보

Meloni, A.R., et al. 2006. Mol. Cell. Biol.26, 7750.
Chen, W., et al. 2004. Science306, 2257.
Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA99, 14071.
Frank-Kamenetsky, M., et al. 2002. J. Biol.1, 10.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable