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AB4073

Sigma-Aldrich

Anti-Farnesyl Antibody

Chemicon®, from rabbit

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About This Item

UNSPSC 코드:
12352203
eCl@ss:
32160702
NACRES:
NA.41
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기술 서비스
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도움 문의

생물학적 소스

rabbit

Quality Level

항체 형태

purified immunoglobulin

항체 생산 유형

primary antibodies

클론

polyclonal

종 반응성(상동성에 의해 예측)

all

제조업체/상표

Chemicon®

기술

ELISA: suitable
immunofluorescence: suitable

배송 상태

wet ice

타겟 번역 후 변형

unmodified

유사한 품목 비교

전체 비교 보기

차이점 표시

1 of 4

이 품목
R8779SAB1300475SAB1300480
biological source

rabbit

biological source

mouse

biological source

rabbit

biological source

rabbit

antibody form

purified immunoglobulin

antibody form

purified from hybridoma cell culture

antibody form

IgG fraction of antiserum

antibody form

IgG fraction of antiserum

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

100

shipped in

wet ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

clone

polyclonal

clone

Rab7-117, monoclonal

clone

polyclonal

clone

polyclonal

technique(s)

ELISA: suitable, immunofluorescence: suitable

technique(s)

immunocytochemistry: suitable, immunoprecipitation (IP): suitable, indirect ELISA: suitable, microarray: suitable, western blot: 0.5-1 μg/mL using HeLa total cell extract

technique(s)

immunohistochemistry: 1:50-1:100, indirect ELISA: 1:1000

technique(s)

indirect ELISA: 1:1000, western blot: 1:100-1:500

일반 설명

Protein isoprenylation is a post-translational modification that affects about 0.5% of cellular proteins and is essential for the biological activity of proteins. Two enzymes catalyze theattachment of two prenyl groups to the sulfhydryl group of carboxyl-terminal cysteine groups. Proteins which are prenylated by these enzymes have a distinct motif at the C-terminal of the protein, C-A1-A2-X (C = Cysteine, A 1 & A2 = aliphatic amino acids). The two enzymes involved in this transfer are farnesyltransferase and geranylgeranyltransferase. These transfer a 15 carbon farnesyl or a 20 carbon geranygeranyl, respectively, from aprenyl-pyrophosphate to the protein. Examples of proteins containing this C-A-A-X motif are members of the Ras small G protein family, the nuclear lamins and the gamma subunit oftrimeric G proteins. Prenylation of proteins is necessary for membrane association of proteins as well as protein-protein interactions and the nature of the linked isoprenyl group can influence the protein interactions, such as the interaction between G proteins and receptors.

특이성

Recognizes farnesyl motif derived from isoprenylated C-A-A-X sequence. Also cross-reacts with geranylgeranyl motif. Detects KLH as well.

면역원

Antibody developed using farnesyl cysteine conjugated to KLH.

애플리케이션

Anti-Farnesyl Antibody detects level of Farnesyl & has been published & validated for use in ELISA & IF.
ELISA

Immunofluoresecence

Optimal working dilutions must be determined by end user.
Research Category
Signaling
Research Sub Category
MAP Kinases

물리적 형태

Format: Purified
Purified immunoglobulin. Sterile liquid in phosphate buffered saline and 0.08% sodium azide.

저장 및 안정성

Maintain at -20°C in undiluted aliquots for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles.

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

법적 정보

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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