Leupeptin is a water-soluble and cell-permeable organic compound. It is produced by various species of actinomycetes and several other fungal families.

Leupeptin has been used as a protease inhibitor supplement in cell lysis buffer for sample preparation.

Leupeptin serves as a lysosomal protease and calpain (serine- and cysteine-like protease) inhibitor. It may be used to reduce the cell death induced by excess calpain activation. Leupeptin confers significant protection against hair cell damage caused by gentamicin ototoxicity. In addition, it also impedes protein degradation in denervated rat muscles and muscles of mice with hereditary muscular dystrophy. Thus, leupeptin may be beneficial in hindering tissue atrophy.

Lyophilized.

Maintain dry at -20ºC for up to 18 months after date of receipt. Store reconstituted product in aliquots at -20ºC for up to 6 months. Avoid repeated thaw freeze cycles.

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