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Merck
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About This Item

실험식(Hill 표기법):
C33H34N6O6
CAS Number:
145040-37-5
Molecular Weight:
610.66
MDL number:
MFCD00871371
UNSPSC 코드:
41116107
NACRES:
NA.24
기술 서비스
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도움 문의

Grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to Ph. Eur. Y0001388
traceable to USP 1087803

API family

candesartan

양식

powder

포장

pkg of 200 mg

응용 분야

pharmaceutical

SMILES string

CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc4ccc(cc4)-c5ccccc5-c6nnn[nH]6

InChI

1S/C33H34N6O6/c1-3-42-32-34-28-15-9-14-27(31(40)43-21(2)44-33(41)45-24-10-5-4-6-11-24)29(28)39(32)20-22-16-18-23(19-17-22)25-12-7-8-13-26(25)30-35-37-38-36-30/h7-9,12-19,21,24H,3-6,10-11,20H2,1-2H3,(H,35,36,37,38)

InChI key

GHOSNRCGJFBJIB-UHFFFAOYSA-N

유전자 정보

human ... AGTR1(185)

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관련 카테고리

일반 설명

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Candesartan cilexetil is an angiotensin II receptor antagonist used as a prodrug in the treatment of hypertension.

애플리케이션

This pharmaceutical secondary standard can also be used as follows:

  • Determination of candesartan cilexetil in tablet formulations by a UV/fluorescence spectrophotometric method
  • Study of the release of candesartan cilexetil in tablet form by reversed-phase high-performance liquid chromatography (RP-HPLC)
  • Simultaneous estimation of candesartan cilexetil and hydrochlorothiazide in pharmaceutical preparations using liquid chromatography in combination with photodiode array detector (DAD) and evaporative light scattering detector (ELSD)
  • Spectroflourimetric determination of four angiotensin II receptor antagonists (AIIRA’s) in their pure form as well as pharmaceutical formulations

생화학적/생리학적 작용

Candesartan cilexetil is a non-peptide angiotensin (AT2) receptor antagonist.
Candesartan cilexetil is the prodrug form of the potent angiotensin II receptor antagonist, candesartan. The prodrug is cleaved by esterases within the intestine to liberate the active molecule.

분석 메모

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

각주

To see an example of a Certificate of Analysis for this material enter LRAB8504 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

추천 제품

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

픽토그램

Health hazard
GHS08

신호어

Danger

유해 및 위험 성명서

H360D,H373

Hazard Classifications

Repr. 1B - STOT RE 2 Oral

표적 기관

Kidney,Blood

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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