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About This Item
실험식(Hill 표기법):
C3H4N2
CAS Number:
Molecular Weight:
68.08
Beilstein:
103853
MDL number:
UNSPSC 코드:
12352200
NACRES:
NA.21
Grade
Molecular Biology
Quality Level
vapor pressure
<1 mmHg ( 20 °C)
제품 라인
Redi-Dri™
분석
≥99% (titration)
양식
crystalline powder
품질
free-flowing
pH
6.2-7.8 (25 °C)
pKa(25 °C)
6.95
bp
256 °C (lit.)
mp
88-91 °C (lit.)
응용 분야
diagnostic assay manufacturing
외래 활성
DNase, RNase and protease, none detected
SMILES string
c1c[nH]cn1
InChI
1S/C3H4N2/c1-2-5-3-4-1/h1-3H,(H,4,5)
InChI key
RAXXELZNTBOGNW-UHFFFAOYSA-N
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일반 설명
Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar.
애플리케이션
Excellent for buffers in the range of pH 6.2-7.8
Imidazole has been used
- in the lysis, wash, and elution buffer for the purification of histidine tagged proteins
- in gradient for the purification of histidine tagged proteins using nickel affinity chromatography
- as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells
생화학적/생리학적 작용
Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division. It also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).
특징 및 장점
- Qualified for molecular biology applications, DNase, Rnase, and protease free
- Redi-Dri™ packaging controls moisture, eliminating clumps
- Crystalline powder remains free-flowing and much easier to use
- Safer to handle and weigh out for routine use in lab
- Less waste, loss of drying, while maintaining high quality
기타 정보
For additional information on our range of Biochemicals, please complete this form.
법적 정보
Redi-Dri is a trademark of Sigma-Aldrich Co. LLC
신호어
Danger
유해 및 위험 성명서
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 1B - Skin Corr. 1C
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 2
Flash Point (°F)
293.0 °F - closed cup
Flash Point (°C)
145 °C - closed cup
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