17946

1α-Hydroxyvitamin D₃

≥97.0% (HPLC)

• 동의어(들): 1α-Hydroxycholecalciferol, Alfacalcidol
• 실험식(Hill 표기법): C₂₇H₄₄O₂
• CAS Number: 41294-56-8
• Molecular Weight: 400.64
• EC Number: 255-297-1
• MDL number: MFCD00868328
• UNSPSC 코드: 12352205
• PubChem Substance ID: 57647693
• NACRES: NA.79

속성

• 생물학적 소스: synthetic
• Quality Level: 200
• 분석: ≥97.0% (HPLC)
• 양식: powder or crystals
• 색상: white to off-white
• 저장 온도: −20°C
• SMILES string: CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C3\C[C@@H](O)C[C@H](O)C3=C
• InChI: 1S/C27H44O2/c1-18(2)8-6-9-19(3)24-13-14-25-21(10-7-15-27(24,25)5)11-12-22-16-23(28)17-26(29)20(22)4/h11-12,18-19,23-26,28-29H,4,6-10,13-17H2,1-3,5H3/b21-11+,22-12-/t19-,23-,24-,25+,26+,27-/m1/s1
• InChI key: OFHCOWSQAMBJIW-AVJTYSNKSA-N
• 유전자 정보: human ... VDR(7421)

설명

일반 설명

1α-Hydroxyvitamin D₃, also known as alfacalcidol, is a synthetic vitamin D₃ analogue, hydroxylated in position one. It is metabolized to 1,25-dihydroxycholecalciferol by 25-hydroxylases.

생화학적/생리학적 작용

1α-Hydroxyvitamin D₃ facilitates calcium absorption and deposition. It also has an ability to inhibit bone resorption and stimulate bone formation. Alfacalcidol is used for treating various bone diseases such as rickets/osteomalacia, renal osteodystrophy and osteoporosis. It acts as a chemopreventive agent and reduces the risk colitis and carcinogenesis.

Synthetic vitamin D₃ analog that is metabolized to 1,25-dihydroxycholecalciferol. Inhibits bone resorption and stimulates bone formation. Supresses parathyroid hormone secretion by bovine parathyroid cells.

포장

Bottomless glass bottle. Contents are inside inserted fused cone.

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H300
• 예방조치 성명서: P301 + P330 + P331 + P310
• Hazard Classifications: Acute Tox. 1 Oral
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges