44707

Acitretin

≥98.0% (HPLC)

• 동의어(들): 9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid
• 실험식(Hill 표기법): C₂₁H₂₆O₃
• CAS Number: 55079-83-9
• Molecular Weight: 326.43
• EC Number: 259-474-4
• MDL number: MFCD00866632
• UNSPSC 코드: 41116107
• PubChem Substance ID: 57650239
• NACRES: NA.25

속성

• Quality Level: 100
• 분석: ≥98.0% (HPLC)
• 양식: powder
• SMILES string: COc1cc(C)c(\C=C\C(C)=C\C=C\C(C)=C\C(O)=O)c(C)c1C
• InChI: 1S/C21H26O3/c1-14(8-7-9-15(2)12-21(22)23)10-11-19-16(3)13-20(24-6)18(5)17(19)4/h7-13H,1-6H3,(H,22,23)/b9-7+,11-10+,14-8+,15-12+
• InChI key: IHUNBGSDBOWDMA-AQFIFDHZSA-N
• 유전자 정보: human ... RARA(5914), RARB(5915), RARG(5916), RXRA(6256), RXRB(6257), RXRG(6258)

설명

애플리케이션

Acitretin, a retinoid that binds to nuclear receptors and regulates gene expression, is a potent activator of the α-secretase ADAM10 gene expression and apoptosis inducer via the CD95 signalling pathway. Acitretin is a systemic retinoid drug used in the treatment of severe psoriasis.

생화학적/생리학적 작용

Synthetic retinoid that is a metabolite of etretinate. Preferentially binds to cellular retinoic acid binding proteins (CRABPs).

안전성 정보

• 픽토그램: GHS07,GHS08,GHS09
• 신호어: Danger
• 유해 및 위험 성명서: H315 - H319 - H360 - H410
• 예방조치 성명서: P201 - P273 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
• Storage Class Code: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges