Name: 7α-Hydroxy-4-cholesten-3-one
Brand: SIGMA

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About This Item

실험식(Hill 표기법):

C₂₇H₄₄O₂

CAS Number:

3862-25-7

Molecular Weight:

400.64

MDL number:

MFCD00870345

UNSPSC 코드:

41116107

PubChem Substance ID:

329757894

NACRES:

NA.24

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도움 문의

Grade

analytical standard

Quality Level

100

분석

≥95.0% (HPLC)

응용 분야

clinical testing

형식

neat

저장 온도

−20°C

SMILES string

O=C1CC[C@@]2(C)C(C[C@@H](O)[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)CCCC(C)C)=C1

InChI

1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1

InChI key

IOIZWEJGGCZDOL-RQDYSCIWSA-N

일반 설명

7α-Hydroxy-4-cholesten-3-one (C4) is known as a marker for the cholesterol 7α-hydroxylase activity. It plays an important role in bile acid metabolism.

애플리케이션

C4 may be used as a reference standard for the determination of C4 in:

Human serum by ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) with electrospray ionization source (ESI) as well as LC-MS.
Rat and monkey plasma by LC-ESI-MS/MS working on multiple reaction monitoring (MRM) mode of detection.
Peripheral blood plasma by solid-phase extraction (SPE) and HPLC.

생화학적/생리학적 작용

7a-Hydroxycholestene-3-one, a metabolite in bile acid synthesis, is derived from 7a-hydroxycholesterol and can be further metabolized to 7a,12a,-dihydroxycholest-4-en-3-one. Analysis of 7a-Hydroxycholestene-3-one (HCO) in serum may serve as a novel, simple, and sensitive method for the detection of bile acid malabsorption in patients with chronic diarrhea of unknown origin.