53300

Histamine dihydrochloride

≥99.0% (AT), powder or crystals, endogenous histamine receptor agonist

• 동의어(들): 2-(4-Imidazolyl)ethylamine dihydrochloride
• 실험식(Hill 표기법): C₅H₉N₃ · 2HCl
• CAS Number: 56-92-8
• Molecular Weight: 184.07
• Beilstein: 3624116
• EC Number: 200-298-4
• MDL number: MFCD00012703
• UNSPSC 코드: 12352116
• eCl@ss: 32160406
• PubChem Substance ID: 329757931
• NACRES: NA.77

속성

• Product Name: Histamine dihydrochloride, ≥99.0% (AT)
• 분석: ≥99.0% (AT)
• 양식: powder or crystals
• 무기 잔류물: ≤0.2%
• 손실: ≤0.2% loss on drying, 20 °C (HV)
• mp: 244-247 °C; 249-252 °C (lit.)
• solubility: H₂O: 0.1 g/mL, clear, colorless
• 음이온 미량물: sulfate (SO₄^2-): ≤200 ppm
• 양이온 미량물: Ca: ≤10 mg/kg; Cd: ≤5 mg/kg; Co: ≤5 mg/kg; Cr: ≤5 mg/kg; Cu: ≤5 mg/kg; Fe: ≤5 mg/kg; K: ≤50 mg/kg; Mg: ≤5 mg/kg; Mn: ≤5 mg/kg; Na: ≤50 mg/kg; Ni: ≤5 mg/kg; Pb: ≤5 mg/kg; Zn: ≤5 mg/kg
• SMILES string: Cl[H].Cl[H].NCCc1c[nH]cn1

설명

일반 설명

Histamine is a hydrophilic amine derived from the decarboxylation of histidine by the enzyme L-histidine decarboxylase. Histamine has been shown to play a role in many physiological processes such as gastric secretion, neurotransmission, immune response, vasodialation, and inflammation. Additionally, studies have reported a role for histamine dihydrochloride with interleukin-2 (IL-2) in treatment of acute myeloid leukemia and in protection against alcohol-induced liver injury in rats.

생화학적/생리학적 작용

Endogenous H₁ and H₂ histamine receptor agonist; activates nitric oxide synthetase; potent vasodilator.

Histamine dihydrochloride has been shown to activate nitric oxide synthetase and suppress or inhibit the generation of reactive oxygen species (ROS). Inhibition of ROS by histamine dihydrochloride allows activation of T cells and NK cells by IL-2. In a rat model, histamine dihydrochloride suppressed ROS generated by Kupffer cells through the H₂ histamine receptor.

기타 정보

Substrate for the assay of histamine-N-methyltransferase (EC 2.1.1.8); Ion-pair extraction of histamine from biological fluids for its determination by HPLC with fluorescence detection.

안전성 정보

• 픽토그램: GHS08,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H315,H317,H319,H334,H335
• 예방조치 성명서: P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Faceshields, Gloves