Name: Adenosine 5′-diphosphate sodium salt
Brand: SIGMA

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About This Item

실험식(Hill 표기법):

C₁₀H₁₅N₅O₁₀P₂

CAS Number:

20398-34-9

Molecular Weight:

427.20

UNSPSC 코드:

41106305

eCl@ss:

32160414

PubChem Substance ID:

24890690

NACRES:

NA.51

기술 서비스

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도움 문의

생물학적 소스

bacterial

Quality Level

300

분석

≥95% (HPLC)

양식

powder

저장 온도

−20°C

SMILES string

[Na].Nc1ncnc2n(cnc12)C3OC(COP(O)(=O)OP(O)(O)=O)C(O)C3O

InChI

1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1

InChI key

XTWYTFMLZFPYCI-KQYNXXCUSA-N

유전자 정보

human ... HSP90AA1(3320), P2RY1(5028)

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일반 설명

Adenosine 5′-diphosphate (ADP) is an adenine nucleotide involved in energy storage and nucleic acid metabolism via its conversion into ATP by FOF1-ATP synthases. ADP can also be obtained by adenylate monophosphate (AMP) reaction catalyzed by adenylate kinase. ADP is a platelet agonist that is secreted from platelet dense granules. It promotes platelet activation through its interaction with ADP receptors P2Y1 and P2Y12. Upon conversion of ADP to adenosine by ecto-ADPases, platelet activation is inhibited via adenosine receptors.

애플리케이션

Adenosine 5′-diphosphate sodium salt has been used:

as a positive control of platelet aggregation to analyze antiplatelet activity of purified disintegrin by aggregometery.
in the preparation of stock solution for a mito stress test.
as a positive control in flow cytometry analysis to study the effect of pentameric C-reactive protein (pCRP) and monomeric CRP (mCRP) on the CD62p (P-selectin) expression of platelets.
as a platelet agonist to stimulate platelet aggregation.