A9106

ADP-ribosylcyclase

1000-3000 units/mg protein

• 동의어(들): Adenosine diphosphoribose cyclase from Aplysia californica
• CAS Number: 135622-82-1
• MDL number: MFCD00212894
• UNSPSC 코드: 12352204
• NACRES: NA.54

속성

• 생물학적 소스: (Aplysia californica)
• Quality Level: 200
• 분석: ≥80 μ protein/vial (BCA)
• 양식: lyophilized powder
• 특이 활성도: 1000-3000 units/mg protein
• 구성: Protein, ≤10%
• 포장: vial of ≥80 μg protein
• 저장 조건: dry at room temperature
• 농도: ≤10% (BCA method)
• 적합성: suitable for enzyme test
• 응용 분야: genomic analysis
• 저장 온도: −20°C

설명

애플리케이션

ADP-ribosylcyclase is a Ca²⁺ signaling second messenger. It may be used to study calcium signaling and has been used to research morphine antinociception and tolerance .

생화학적/생리학적 작용

ADP-ribosylcyclase is an intracellular calcium regulator that cyclizes NAD into cADPR. It is thought that the majority of ADP-ribosylcyclase activity in the brain is linked to CD38. Nicotinamide is a known inhibitor of CD38 ADP-ribosylcyclase activity .

단위 정의

One unit will produce 1 μmole of cyclic ADP ribose from β-NAD⁺ in 5 minutes at pH 7.0 and 25°C.

물리적 형태

Lyophilized powder containing trehalose, potassium phosphate and dithiothreitol

안전성 정보

• 픽토그램: GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H334
• 예방조치 성명서: P261 - P284 - P501
• Hazard Classifications: Resp. Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)