B5399

(±)-Baclofen

≥98% (HPLC), solid

• 동의어(들): (±)-β-(Aminomethyl)-4-chlorobenzenepropanoic acid, Lioresal
• 실험식(Hill 표기법): C₁₀H₁₂ClNO₂
• CAS Number: 1134-47-0
• Molecular Weight: 213.66
• EC Number: 214-486-9
• MDL number: MFCD00055143
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24278146
• NACRES: NA.32

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: solid
• 색상: white to very faintly yellow
• solubility: 1 M HCl: 50 mg/mL
• 저장 온도: 2-8°C
• SMILES string: ClC1=CC=C(C(CN)CC(O)=O)C=C1
• InChI: 1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)
• InChI key: KPYSYYIEGFHWSV-UHFFFAOYSA-N
• 유전자 정보: human ... GABBR1(2550), GABBR2(9568) ; rat ... Gabbr1(81657), Gabra2(29706)

설명

애플리케이션

(±)-Baclofen has been used as γ-aminobutyric acid receptor B GABA_B receptor agonist:

• as well as control GABAergic drug to test its protective effects on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic toxicity
• to test its effects on in vivo motor function tests and performance of mutant mice
• to test its excitability effect on dopaminergic (DA) neurons of the ventral tegmental area (VTA)
• to test its effect in reducing dendritic excitability in Purkinje neurons

생화학적/생리학적 작용

Baclofen, a γ-aminobutyric acid (GABA) analog, possesses myorelaxant properties Being a γ-aminobutyric acid receptor B (GABA_B) agonist, baclofen may be involved in the potentiation of dendritic potassium K⁺ channels. It may be useful in blocking transient lower esophageal sphincter relaxation (TLESR) in gastroesophageal reflux disease (GERD). Baclofen may also have scope for treating addictive especially, in alcohol use disorder (AUD).

GABA_B receptor agonist; skeletal muscle relaxant; antispastic agent.

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H301
• 예방조치 성명서: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges