Name: Cerulenin
Brand: SIGMA

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About This Item

실험식(Hill 표기법):

C₁₂H₁₇NO₃

CAS Number:

17397-89-6

Molecular Weight:

223.27

Beilstein:

4140423

EC Number:

241-424-8

MDL number:

MFCD00083595

UNSPSC 코드:

51111800

PubChem Substance ID:

24892323

NACRES:

NA.77

기술 서비스

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도움 문의

Product Name

Cerulenin, ≥98% (HPLC), from Cephalosporium caerulens

생물학적 소스

Cephalosporium caerulens

Quality Level

200

분석

≥98% (HPLC)

양식

powder

mp

93 °C

solubility

acetone: 19.60-20.40 mg/mL, clear to slightly hazy, colorless to yellow

항생제 활성 스펙트럼

fungi

동작 모드

enzyme | inhibits

저장 온도

−20°C

SMILES string

C/C=C/C/C=C/CCC([C@@H]1[C@H](C(N)=O)O1)=O

InChI

1S/C13H18O3/c1-3-4-5-6-7-8-9-11(15)13-12(16-13)10(2)14/h3-4,6-7,12-13H,5,8-9H2,1-2H3/b4-3+,7-6+/t12-,13+/m0/s1

InChI key

PTNNGEBMCNMENY-JIVMHGEESA-N

유전자 정보

human ... FASN(2194)

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일반 설명

Cerulenin, an inhibitor of de novo phospholipid synthesis triggers apoptosis in various wild type p53 and mutant p53 tumor cell lines. This fungal antibiotic also blocks the condensing enzyme involved in fatty acid and polyketide biosynthesis.

애플리케이션

Cerulenin has been used:

as a fatty acid synthase inhibitor to study its effects on aldosterone-induced trained immunity
as a blocker of fatty acid synthase to study its effects on the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2)
as a supplement in yeast extract–peptone–dextrose/glycerol (YPD/G) agar plates for the isolation of cerulenin-resistant yeast strains