Name: Carbonyl Cyanide m-Chlorophenylhydrazone
Brand: SIGMA

로그인조직 및 계약 가격 보기

About This Item

실험식(Hill 표기법):

C₉H₅ClN₄

CAS Number:

555-60-2

Molecular Weight:

204.62

Beilstein:

1842102

EC Number:

209-103-7

MDL number:

MFCD00001848

UNSPSC 코드:

12352200

PubChem Substance ID:

24892523

NACRES:

NA.77

기술 서비스

도움이 필요하신가요? 저희 숙련된 과학자 팀이 도와드리겠습니다.

도움 문의

Product Name

Carbonyl cyanide 3-chlorophenylhydrazone, ≥97% (TLC), powder

Quality Level

200

분석

≥97% (TLC)

양식

powder

색상

yellow to orange

solubility

DMSO: 100 mM

저장 온도

−20°C

SMILES string

Clc1cccc(N\N=C(\C#N)C#N)c1

InChI

1S/C9H5ClN4/c10-7-2-1-3-8(4-7)13-14-9(5-11)6-12/h1-4,13H

InChI key

UGTJLJZQQFGTJD-UHFFFAOYSA-N

유사한 제품을 찾으십니까? 방문 제품 비교 안내

애플리케이션

Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) has been used:

in the inhibition of efflux pump in clinical Pseudomonas aeruginosa
to inhibit oxidative phosphorylation activity of mitochondria in human Beas-2B bronchial epithelial cells
to prepare carbonyl cyanide m-chlorophenylhydrazone solution for oxidative and mitochondrial stress assay and mitophagy induction in Caenorhabditis elegans

생화학적/생리학적 작용

Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) induces mitophagy in mammalian cells. CCCP suppresses the expression of few electron transport chain (ETC) proteins. Protonophore (H⁺ ionophore) and uncoupler of oxidative phosphorylation in mitochondria. Shown to have a number of effects on cellular calcium. Inhibits secretion of hepatic lipase and partially inhibits the pH gradient-activated Cl^- uptake and Cl^-/Cl^- exchange activities in brush-border membrane vesicles.